Tuberculosis

CD1-restricted T cell repertoire limited to cross-reactive antigens in TB

Published in Blood Weekly, May 19th, 2005

The CD1-restricted T cell repertoire is limited to cross-reactive antigens in tuberculosis.

According to published research from the United States, "The repertoires of CD1- and MHC-restricted T cells are complementary, permitting the immune recognition of both lipid and peptide Ags, respectively.

"To compare the breadth of the CD1-restricted and MHC-restricted T cell repertoires, we evaluated T cell responses against lipid and peptide Ags of mycobacteria in leprosy, comparing tuberculoid patients, who are able to restrict the pathogen, and lepromatous patients, who have disseminated infection."

"The striking finding was that in...

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Source: Blood Weekly (2005-05-19)

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