Diagnostics

Using NRBCs to determine fetal gender and hemophilia A status is questionable

Published in Blood Weekly, May 19th, 2005

Based on recent study results, the use of nucleated red blood cells in maternal plasma is of questionable clinical use to determine fetal gender.

Researchers also attempted to reveal fetal hemophilia A status via Bc1I DNA polymorphism.

J. Choe and colleagues, Hamchoon Women's Clinic, Seoul, wrote, "Venous blood was drawn from 20 pregnant women, and NRBCs were recovered by magnetic activated cell sorting and anti-GPA (glycophorin A) immunostaining. After microdissector isolation of the NRBCs, primer extension preamplification (PEP) and nested polymerase chain reaction of the amelogenin gene were performed to determine fetal gender. We also performed...

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Source: Blood Weekly (2005-05-19)

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