Published in Blood Weekly, May 19th, 2005
Study 1: SP1 sequence mutation impairs HIV-1 Gag multimerization and membrane-binding activities.
"Although SP1 is known to be indispensable for virus production, the mechanisms involved are mostly unclear. In this study, we demonstrate that an M368A mutation within SP1 severely diminished the ability of Gag to associate with cellular membranes."
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