Blood Weekly

Leukemia - Gene mutations in TRAIL receptors were absent in chronic myelogenous leukemia

Leukemia - Giving children access to drug trials is crucial, clofarabine approval shows

Leukemia - Recurrent abnormality in chronic and acute leukemia fused PCM1 to JAK2

Lymphoid Development - Frizzled 9 knock-out mice have abnormal B-cell development

Malaria - Exposure to holoendemic malaria results in elevated EBV loads in children

Medical Malpractice - Medical-legal issues debated surrounding ICU-acquired MRSA-associated death

Melanoma - Melanoma cells express elevated levels of phosphorylated histone H2AX foci

Melanotransferrin - Distribution of transferrin homologue, melanotransferrin examined

Meningitis - Meningococcal disease epidemic may be controlled by strain-specific OMV vaccine

Multiple Sclerosis - HSCT induces long-lasting suppression of inflammation in multiple sclerosis

Mycobacteria - Polyketide synthases generate complex lipids in mycobacteria

Mycobacterium Avium -  M. avium PPE gene associated with virulence/ability to grow in macrophages

Mycobacterium Kansasii -  M. kansasii virulence not directly related to ESAT-6/CFP-10 gene expression

Mycobacterium Smegmatis - FadD32 and accD4 genes essential for survival of Mycobacterium smegmatis

Mycobacterium Tuberculosis - Dual role determined for N-terminal region of Mycobacterium tuberculosis

Nanobacterial Protein - Global warming may accelerate primordial nanobacterial proteins reaching earth

Neural Stem Cell Research - PACAP promotes differentiation of neural stem cells into astrocytes

Neural Stem Cell Research - Smad4 or Cripto deletion is not sufficient to block nonneuronal tissue formation

Neural Stem Cell Research - TRPC1 contributes to bFGF/FGFR-1-induced Ca2+ influx

Neural Stem Cell Research - Tumor cells attract endogenous precursor cells whose presence is antitumorigenic

Neurotoxin Exposure - Pre/postnatal exposure to lead alters neuromotor function in preschool children

Obstetrics - Researchers' work adds to obstetrics body of knowledge

Occupational Safety - Scalpel-free surgery could reduce risk of HIV exposure for healthcare workers

Osteoporosis - Children on long-term warfarin have reduced bone density

Paralytic Shellfish Poisoning - Environmental factors control dinoflagellate growth associated with poisoning

Patents - Biotechnology company files new patent for stem cell therapy for diabetes

Pediatric Leukemia - CpG islands of p15INK4B gene in childhood acute leukemia were hypermethylated

Personnel - Therapeutics company announces promotion

Physiology - Physical fitness affects older women's hemostatic profiles more than HRT

Proteomics - Angiostatin and plasminogen share endothelial cell binding motifs

Renal Disease - Bone marrow-derived cells stem the progression of glomerulonephritis

Respiratory Syncytial Virus - CTL epitopes are RSV subtype A-specific and may not be recognized in subtype B

Rous Sarcoma Virus - C-terminal of TSG101 blocks Rous sarcoma virus budding

SARS Coronavirus - SARS CoV 3CL(pro) indispensable for proteolytic activity/not enzyme dimerization

SARS Outbreaks - Researchers publish new studies and findings in the area of SARS ouTBreaks

Squamous Cancer - T-cadherin negatively regulates cutaneous squamous carcinoma proliferation

Statins - Octreotide can mimic ischemic PC to reduce infarct size

Stem Cell Disorders - Acquired PTPN11 mutations rarely occur in myelodysplastic syndromes and CMLL

Stem Cell Donor Search - Inefficient search process is reason that finding compatible HSC donor fails

Stem Cell Research -  Dugesia japonica PCNA is a useful tool for identifying planarian neoblasts

Stem Cell Research - Boost HSC decreases donor chimerism/graft dysfunction in PID patients

Stem Cell Research - Company comments on proposed initiative to fund cord blood bank

Stem Cell Research - Corneal epithelium transdifferentiation into epidermis via multistep process

Stem Cell Research - Enforced Bcl-2 expression overrides serum/feeder cell needs for ESC self-renewal

Stem Cell Research - G-CSF induces stabilization of ETS protein Fli-1 during myeloid cell development

Stem Cell Research - Multipotent cells isolated from human term placenta

Stem Cell Research - Stem cells secrete a cytokine that helps repair infarcted myocardium

Stem Cell Research - TNF-alpha has suggested role in regulatory activity of CD34+ cells

Stem Cell Transplantation - Elevated T-1 cells prior to ASCT increases acute graft-versus-host disease risk

Stem Cell Transplantation - G-CSF affects serum levels of soluble IL-2 receptors following ASCT

Stem Cell Transplantation - HLA-haploidentical nonmyeloablative SCT successful in PBSCT-resistant patient

Stem Cell Transplantation - Outcome not improved with higher-dose therapy to reduce relapse after SCT in AML

Stem Cell Transplantation - Pilocarpine has no benefit for the moderation of oral mucositis during ASCT

Stem Cell Transplantation - Reduced intensity ASCT feasible for low-grade non-Hodgkin lymphoma in elderly

Stem Cell Transplantation - Unmodified AHSCT from KIR ligand-incompatible donors provides long-term efficacy

Stem-Cell Transplantation - Denileukin diftitox shows promise for treatment of steroid-resistant aGVHD

Surgery - Gene variants predict bleeding after heart surgery

Surgical Technology - FDA clears Surgisis AFP Fistula Plug for fistula repair

T-Cell Large Granular Lymphocyte Leukemia - Epitope defined for HTLV env seroreactivity observed in LGL leukemia

Thrombotic Risk Factors - Factor VIII D1241E polymorphism associated with decreased factor VIII activity

Tissue Engineering - Bacterial cellulose is potential scaffold for cartilage tissue engineering

Tissue Engineering - Functional muscle rapidly formed with fibrin gels

Tissue Engineering - Hydrophobicity is design criterion for bone tissue engineering polymer scaffolds

Tissue Engineering - IDVC algorithm determines 3D strain state inside largely deformed collagen ECMs

Tissue Engineering - OCT-1 osteoblast-like cell adhesion enhanced on rough surface texture

Tissue Engineering - Solid 3-dimensional polymers grows stem cell-derived neurons

Transplant Medicine - Ribavirin promotes liver fibrosis in HCV-positive kidney recipients

Tuberculosis - Poor emotional quality-of-life persists even after tuberculosis treatment

Tuberculosis - Pyruvate requirement of some MTB complex members due to inactive pyruvate kinase

Tuberculosis - Secreted MTB chorismate mutase evolved to participate in parasitism/pathogenesis

Tuberculosis Vaccine - Tuberculosis vaccines have entered preclinical studies

Type 2 Diabetes - Treatment of metabolic syndrome challenging for pediatric endocrinologists

Umbilical Cord Blood Transplantation - Herpesvirus transmission risk through cord blood transplantation assessed

Virology - Researchers' findings advance virology research

Virus Activation - K-Rta essential for lytic viral reactivation and transactivation of viral genes