Tick-Borne Fever

Cellular genes identified in response to A. phagocytophilum infection

Published in Blood Weekly, May 26th, 2005

Cellular genes that are expressed in response to A. phagocytophilum infection have been identified.

"Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae) causes human, equine and canine granulocytic anaplasmosis and tick-borne fever of ruminants. The rickettsia parasitizes granulocytes and bone marrow progenitor cells, and can be propagated in human promyelocytic and tick cell lines.

"In this study, microarrays of synthetic polynucleotides of 21 329 human genes were used to identify genes that are differentially expressed in HL-60 human promyelocytic cells in response to infection with A. phagocytophilum," scientists in the...

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Source: Blood Weekly (2005-05-26)

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