Leishmaniasis

Membrane-assoc. Leishmania Ags induce CBMC/PBMC from noninfected individuals

Published in Blood Weekly, May 26th, 2005

Membrane-associated Leishmania antigens induce umbilical cord blood mononuclear cells and peripheral blood mononuclear cells from noninfected individuals.

"Membrane-associated Leishmania Ags (MLA) or soluble Leishmania Ags were used in vitro to stimulate cord blood or PBMC from healthy donors noninfected by Leishmania parasites.

"MLA, but not soluble Leishmania Ags, constantly induce strong proliferation of cord blood mononuclear cells-and PBMC from noninfected individuals. Responding cells are CD3+, CD4+, TCRalphabeta+, CD45RO+, and CD45RA+ and secrete IFN-gamma and IL-10, but not IL-4," investigators in Tunisia report.

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Source: Blood Weekly (2005-05-26)

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