Neural Stem Cell Research
Adult neural stem cell cycling requires thyroid hormone and its alpha receptor
Published in Blood Weekly, June 2nd, 2005
"Thyroid hormones (TH) are essential for brain development. However, information on if and how this key endocrine factor affects adult neurogenesis is fragmentary.
"We thus investigated the effects of TH on proliferation and apoptosis of stem cells in the subventricular zone (SVZ), as well as on migration of transgene-tagged neuroblasts out of the stem cell niche," researchers in France report.
"Hypothyroidism significantly reduced all three of these processes, inhibiting generation of new cells. To determine the mechanisms relaying TH action in the...
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Source: Blood Weekly (2005-06-02)
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