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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . June 16th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Anemia - Hemoglobin raffimer used for severe anemia in Jehovah's Witness

Stem Cell Research - Transplanted B-stem cells reconstitute bone marrow B-cells after irradiation

Tissue Engineering - MSCs engineered for total ankle joint repairs for osteoarthritis

Umbilical Cord Blood Banking - Umbilical cord blood banking promises families biological "insurance"

Umbilical Cord Blood Transplantation - Modified cord blood collection method achieves sufficient cell levels for CBT

Acute Myeloid Leukemia - New findings in acute myeloid leukemia described

Aging - Insulin resistance, weight gain lead to early aging

Alzheimer Disease - Beta-site specific intrabodies prevents generation of Alzheimer A beta peptide

Anemia - Clinical implications of cancer-related anemia on quality of life examined

Angiology - Impedence cardiography effective for reducing blood pressure, study shows

Angiology - Laser-made channels and progenitor cells spawn new vessels in ischemic limbs

Angiology - Recent studies add new data to angiology research

Antibiotic Resistance - Pathogens can have a strong effect on host behavior

Anticoagulant Therapy - Dalteparin doesn't influence lupus anticoagulant test results

Aplastic Anemia - Third course of ATG for aplastic anemia an option only for previous responders

Biomedical Engineering - Re-engineered autologous T cells attack non-Hodgkin lymphoma cells

Bloodstream Infection - Categorization and blood culture Gram stains can guide early treatment

Breast Cancer - HER-2 overexpression inversely correlates with ER/PR expression in breast cancer

Business & Finance - Company focused on lipids-associated diseases reports Q1 2005 results

Business Update - Company continues capacity expansion for dialyzers

Business Update - Supply agreement inked for surgical blood salvage technology in U.S.

Cancer Research - Combretastatin A4 Prodrug trial indicates antitumor activity

Cancer Therapy - Companies announce agreement with NCI for PXD101

Cardiac Stem Cell Research - Directing cardiac fate in stem cells is necessary for regeneration

Cardiology - Researchers' work adds to cardiology body of knowledge

Central Nervous System - Central nervous system involved in posttransplant lymphoproliferative disorder

Chemotherapy - Single-agent chemotherapy used for posttransplant lymphoproliferative disorder

Chronic Liver Disease - TT virus coinfection accounts for some liver disease cases in India

Colon Cancer - Five-year survival lower in transplant recipients compared with general populous

Colorectal Cancer - Screening behavior characterized in Hong Kong Chinese population

Contraception - Studies presented at meeting showing efficacy of vaginal ring for contraception

Critical Care - Improvements decrease risk of post-injury multiple organ failure

Cryogenics - "Cool" blood stem cell research leads to licensing deal

Diagnostics - LC method for quantification of whole-blood everolimus validated

Diagnostics - Rapid HIV assays qualified for sale in the Republic of Uganda

Diagnostics - Researchers report details of new studies and findings in the area of diagnostics

Drug Delivery - Carboxy methyl dextran hydrogel is pH- and ionic-strength-sensitive

Drug Delivery - New method of administering anticancer drug may be more effective, safer

Drug Delivery - PEG/PLA semiinterpenetrating network controls delivery of protein drugs

Drug Delivery - Recombinant adenovirus vector expresses IL-2 and myelomonocytic growth factor

Embryonic Stem Cell Research - Autogeneic feeder cell system supports growth of undifferentiated ESCs

Embryonic Stem Cell Research - ESC ectopic mTERT expression confers resistance to p53-dependent apoptosis

Embryonic Stem Cell Research - Identified growth factors allow direct hepatic fate-specification from ESCs

Embryonic Stem Cell Research - Matrigel used as substrate for feeder-free propagation of undifferentiated ESCs

Embryonic Stem Cell Transplantation - ESC-derived microglia-like cells migrate into brain but not peripheral tissues

Finance - Maker of interventional surgical cardiology systems reports Q1 2005 results

Gastroenterology - Hepatic arterial infusion chemotherapy treated sarcoma liver metastases

Genital Herpesvirus Prevention - Topical microbicides being developed to prevent genital herpes infection

HIV/AIDS Diagnostics - Dried blood spots improve access to HIV diagnosis in infants

HIV/AIDS Diagnostics - One-step nested PCR monitors HIV replication

HIV/AIDS Diagnostics - Rapid HIV testing has reduced test results from days to minutes

HIV/AIDS Drug Development - Developed HIV-1 protease inhibitors active against multidrug-resistant virus

HIV/AIDS Drug Development - Developed tricyclic phtalimide analogues inhibit HIV-1 integrase

HIV/AIDS Drug Development - Low molecular weight HIV-1 protease dimerization inhibitors developed

HIV/AIDS Drug Development - Lysozyme nonapeptide HL9 has anti-HIV activity

HIV/AIDS Drug Development - Method predicts structure-based activity of HIV-1 RT inhibitors

HIV/AIDS Drug Resistance - Antiretroviral resistance not a major determinant of disease progression/death

HIV/AIDS Epidemiology - HIV infection rate not significantly changed among adolescents in South Africa

HIV/AIDS Epidemiology - Multiple partners and unprotected sex fuel HIV/AIDS epidemic in Africa

HIV/AIDS HAART - Adverse experiences increased following quadruple-drug induction HAART

HIV/AIDS Nutrition - Fruit/vegetable increase improves oxidative stress indicators in HIV/AIDS

HIV/AIDS Pathogenesis - CD4 engagement-induced cell surface rearrangement facilitates HIV entry

HIV/AIDS Pathogenesis - CD81 increases HIV-1 gene expression in CD4 cells via transcription factors

HIV/AIDS Pathogenesis - HIV Gag concentrates in specific plasma membrane areas rapidly after translation

HIV/AIDS Pathogenesis - HIV-1 gp120 regulates cxcr4-mediated signaling in neural progenitor cells

HIV/AIDS Pathogenesis - HIV-1-induced macrophage gene expression includes the p21 gene

HIV/AIDS Pathogenesis - HIV-1-specific CTL responses in blood mirror mucosa in natural chronic infection

HIV/AIDS Pathogenesis - JM4 is a four-transmembrane protein binding to CCR5 receptor

HIV/AIDS Pathogenesis - Kinetic factors control HIV-1 cell entry efficiency/entry inhibitor efficacy

HIV/AIDS Pathogenesis - Rad3-related protein and GADD45 alpha mediate HIV-1 Vpr-induced apoptosis

HIV/AIDS Pathogenesis - TFII-I regulates induction of HIV-1 LTR in cooperation with USF

HIV/AIDS Pathogenesis - TNF-alpha stimulates HIV-1 production in adipocytes

HIV/AIDS Prevention - Most rural health institutions in Ethiopia report reusing needles/syringes

HIV/AIDS Research - Inverse relationship between heparin binding by HIV gp120 and its thiol content

HIV/AIDS Vaccines - Research in HIV/AIDS vaccines provides new insights

HIV/AIDS Vertical Transmission - CD4 count and HIV RNA are independent risk factors for mortality after delivery

HIV/AIDS-Related Disorder - HIV-related pulmonary hypertension does not worsen with HAART interruption

HIV/AIDS-Related Infection -  Acinetobacter baumannii folliculitis detected in patient with AIDS

HIV/AIDS-Related Infection -  Mycobacterium peregrinum infection identified in AIDS patient

HIV/AIDS-Related Infection - Rarely diagnosed cardiac aspergillosis is fatal in HIV-infected patients

HTLV-1-Assoc. Myelopathy/Trop. Spastic Paraparesis - IFN-beta 1a benefits immune mechanisms central to HAM/TSP pathogenesis

Hematology - Angiogenic cytokine bolsters chronic lymphocytic leukemia

Hematology - Researchers provide details of new studies and findings in the area of hematology

Hepatitis C - Study examines two approaches for liver disease treatment

Hepatitis C Epidemiology - Hepatitis C is rarely sexually transmitted between men who have sex with men

Hypercholesterolemia - U.S. FDA approves generic drug for treatment of hypercholesterolemia

Hypertension - ATHOS study results presented at geriatric conference

Hypertension - New mouse aids understanding of plasma volume and blood pressure

Hypoxia - Hypoxia and anemia affected tumor biology and treatment resistance

Infectious Disease Research - NIAID-supported research combats/elucidates emerging infectious diseases

Kaposi Sarcoma-Associated Herpesvirus - Recent findings in kaposi sarcoma-associated herpesvirus described

Kidney Cancer - Donor kidneys with small renal cell cancers deemed viable for transplantation

Kidney Transplantation - Administration methods of antithymocyte globulins in renal transplant patients

Kidney Transplantation - Renal transplant recipients with mutant hepatitis B should continue lamivudine

Krabbe Disease - Umbilical cord-blood transplants save lives of babies with rare genetic disorder

Leukemia - Cooperative effect of p12, CA during early events of MLV replication is possible

Leukemia - Disease status of CML patients characterized by BCR-ABL/BCR transcript ratio

Leukemia - Leukemia prognosis predicted with HS1

Leukemia - Microsatellite instability found in patients with chronic B-cell leukemia

Leukemia - New data illuminates research in leukemia

Leukemia - Survival of a child with ALL and Scedosporium prolificans infection examined

Liver Cancer - Advanced liver cancer treated with high-intensity focused ultrasound ablation

Liver Cancer - Risk factors of HCC recurrence in living donor liver transplantation clarified

Liver Transplantation - Domino liver transplantation performed in living donors

Liver Transplantation - Excellent liver transplant survival rates predicted under MELD/PELD system

Lung Cancer -  M. tuberculosis infection associated with FHIT gene LOH in lung cancer

Lung Cancer - Monoclonal antibiody Bevacizumab trial results announced

Lymphocytic Leukemia - Updated analysis from trial of lymphocytic leukemia therapy reported

Lymphoma - CXCR3-positive B cells attracted by MIG might belong to the lymphoma clone

Malaria - Reports describe recent advances in malaria research

Medical Devices - Company announces release of new ausculatatory stress blood pressure monitor

Meningitis - Distinct lineage of echovirus 30 probable cause of aseptic meningitis outbreak

Methicillin-Resistant Staphylococcus Aureus - Soap-sharing/pre-existing cuts caused recurring MRSA infections in football team

Multiple Myeloma - Data on early administration VELCADE for multiple myeloma reported

Mycobacterium Smegmatis -  M. smegmatis mutants unable to grow at low pH in the presence of CCCP

Mycobacterium Smegmatis -  M. smegmatis re1A homolog affects cell appearance/viability/gene expression

Mycobacterium Tuberculosis - MTB mycolic acid elicits pathogen-associated host innate immune responses

Myeloproliferative Disorders - Dominant gain-of-function JAK2 mutation common in patients

Neural Stem Cell Research - Glial-derived nexin transforms HEK cells into neuron-like cells

Neural Stem Cell Research - Nandrolone influences neural stem cell proliferation and neurogenesis

Neural Stem Cell Research - P21 loss compromises adult neural stem cell relative quiescence

Neural Stem Cell Research - Simultaneous Olig2/Nkx2.2 cDNA transfection differentiates oligodendrocytes

Neurogenesis - D3 dopamine receptors do not regulate neurogenesis in subventricular zone

Norovirus - Factors identified with bovine norovirus seropositivity in veterinarians

Norovirus Outbreaks - GII/5 was dominant genotype in norovirus outbreak in Japan

Nuclear Magnetic Resonance - F-19 NMR is a versatile reporter for non-invasive physiology and pharmacology

Nucleopolyhedrovirus - Nucleopolyhedrovirus epizootics initiate decline of N. abietis populations

Obesity Epidemic - Obesity epidemic is harbinger of metabolic disorder epidemic

Obstetrics - Coagulation status linked to mid-trimester loss, but not later complications

Obstetrics - Etiology of nonimmune fetal hydrops studied in southern Thailand

Obstetrics - Study probes mechanism of hemostasis during normal pregnancy

Organ Donation - Gender imbalance in living kidney donation found in Switzerland

Parkinson Disease - Mouse gene accounts for blood abnormalities as well as Parkinson symptoms

Patents - Company receives broad U.S. patent covering automated process for NAT system

Personnel - Cell therapy company adds members to scientific advisory board

Personnel - Regenerative medicin-focused company adds 2 to clinical development team

Pharmaceutical Research - Patients on warfarin have fewer complications with anticoagulation service

Prostate Cancer - Intraoperative cell salvage not linked to greater biochemical recurrence rate

Prostate Cancer - Management of anesthesia during prostate surgery analyzed

Pulmonary Medicine - Greater cord blood VEGF in preterm infants signals less respiratory distress

Quality Assurance - Tutogen Medical Earns AATB Accreditation

Rabies - Stochastic special model predicts spatial dynamics for raccoon rabies emergence

Radiotherapy - Hemoglobin levels associated with acute radiotherapy-induced toxicity

Renal Disease - Bone marrow cells buoy glomerular endothelial cell regeneration

Renal Failure - Sirolimus may regress Kaposi sarcoma in renal graft recipients

Retroviruses - TRIM5 alpha proteins block retrovirus infections across primate species

SARS Coronavirus - Anti-SARS-coronavirus activity of cepharanthine determined

Simian Immunodeficiency Virus - Active SIV CNS infection correlates with neurological disease

Spinal Cord Regeneration - Corticospinal regeneration into lumbar gray matter reason for locomotor recovery

Stem Cell Research - Activated CB DCs kill tumor cells without damaging normal hematological SCs

Stem Cell Research - Basic FGF supports undifferentiated ESC growth without conditioned medium

Stem Cell Research - Embryonic stem cells extend survival in rats with experimental liver failure

Stem Cell Research - Genetically modified mesenchymal stem cells heal neurological disorders

Stem Cell Research - Intervertebral disc-like cells induced from adult mesenchymal stem cells

Stem Cell Research - Nestin-positive mesenchymal SCs differentiate into excitable neuron-like cells

Stem Cell Research - Notch has role in regulating exocrine progenitor pool

Stem Cell Research - Pit-1 induces hepatic SC differentiation into prolactin-producing cells

Stem Cell Research - Publication describes animal cell-free derivation of human embryonic stem cells

Stem Cell Research - Scientists join to develop laboratory model of immune system

Stem Cell Research - Three type of ionic currents identified in mesenchymal stem cells from BM

Stem Cell Research - Valproic acid stimulates proliferation/self-renewal of hematopoietic stem cells

Stem Cell Transplantation - Embryonic stem cells may be future therapy for inner ear diseases

Stem Cell Transplantation - Fc gamma RIIa-polymorphic site potential target for acute GVHD in allogeneic SCT

Stem Cell Transplantation - Higher CD34 cell dose can reduce pulmonary mortality after TBI-based regimens

Stem Cell Transplantation - New data illuminates research in stem cell transplantation

Stem Cell Transplantation - Race associated with survival after ASCT from IIIA-matched unrelated donors

Stem Cell Transplantation - Thymic recovery onset/thymic output plateau differentially regulated after SCT

Thalassemia - HRI protein has protective role in red cell disorders

Tissue Engineering - 3D femtosecond laser patterning of collagen used for directed cell attachment

Tissue Engineering - Bioactive glasses able to modulate macrophages and monocytes

Tissue Engineering - Chitin-based tubes used for tissue engineering in nervous system

Tissue Engineering - Endothelial cells proliferate on adhesive protein-free synthetic polymer gels

Tissue Engineering - Endothelium directly cocultured on smooth muscle cells

Tissue Engineering - Minimal porous PPF scaffold degradation occurs following implantation

Tissue Engineering - Nanoporous alumina membranes improve osteoblast adhesion and proliferation

Tissue Engineering - Reports advance knowledge in tissue engineering research

Transplant Medicine - Campath 1H induction reduces acute rejection after liver transplantation

Transplant Medicine - Certican approved by Swissmedic to reduce risk of organ rejection

Transplant Medicine - DR antigens sway hepatitis C recurrence and liver graft outcomes

Transplant Medicine - Donor livers from octogenarians thrive after transplantation

Transplant Medicine - Long-term outcomes studied for stem cell transplant recipients

Transplant Medicine - Successful renal transplantation is good for the heart

Transplant Medicine - U.S. FDA OKs phase 2b kidney transplant trial for immunosuppressive drug

Transplantation Medicine - Careful cardiac evaluation necessary post-transplant

Transplantation Medicine - New crossmatch technique eliminates antibody interference

Tuberculosis - Ipr1 gene mediates innate immunity to tuberculosis

Tuberculosis - Multiple factors influence inability to control tuberculosis in China

Tuberculosis - PI3P retention different in phagosomes containing live or dead mycobacteria

Tuberculosis - Tuberculosis decline in Netherlands over the past decade result of cohort effect

Tuberculosis Drug Development - Quinoxaline-2-carboxylate 1,4-dioxide derivatives have anti-MTB activity

Yersinia Pestis -  Y. pestis CRISPR elements acquire new repeats by bacteriophage DNA uptake

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