Published in Blood Weekly, June 16th, 2005
"Kaposi sarcoma (KS) is a rare complication of renal transplantation in Poland (in our center 2 of 1000 patients). Neovascularization (typical for KS) is promoted by KS-related vascular endothelial growth factor (t-r-VEGF)," scientists writing in the journal Transplantation Proceedings report.
"Sirolimus may reduce t-r-VEGF synthesis and inhibit P13K-p70(S6) kinase of endothelial cells. Two men, 58 and 51 years old, were transplanted in 2002. Initial immunosuppression consisted of cyclosporine, azathioprine, and prednisone. In the second patient, at the week 8 the...
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