Stem Cell Research
Notch has role in regulating exocrine progenitor pool
Published in Blood Weekly, June 16th, 2005
According to a recently published review from the United States, "Changes in epithelial differentiation represent a characteristic early feature of human pancreatic cancer. Recent work suggests that many of these changes may reflect a pathologic recapitulation of developmental events."
"Reflecting this principle, metaplastic and neoplastic pancreatic epithelium appear to share many features in common with embryonic pancreatic epithelium, including reactivation of the Notch signaling pathway," wrote S.D. Leach and colleagues at Johns Hopkins University,
"In this review,"...
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Source: Blood Weekly (2005-06-16)
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