HIV/AIDS Pathogenesis

CD4 engagement-induced cell surface rearrangement facilitates HIV entry

Published in Blood Weekly, June 16th, 2005

CD4 engagement-induced cell surface rearrangement facilitates HIV entry.

According to recent research published in the journal Experimental Cell Research, "T cell polarization and redistribution of cellular components are critical to processes such as activation, migration, and potentially HIV infection.

"Here, we investigate the effects of CD4 engagement on the redistribution and localization of chemokine receptors, CXCR4 and CCR5, adhesion molecules, and lipid raft components including cholesterol, GM1, and glycosyl-phosphatidylinositol (GPI)-anchored proteins."

"We demonstrate that anti-CD4-coated beads (alpha CD4-B)...

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Source: Blood Weekly (2005-06-16)

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