HIV/AIDS Pathogenesis

HIV-1 gp120 regulates cxcr4-mediated signaling in neural progenitor cells

Published in Blood Weekly, June 16th, 2005

HIV-1 gp120 regulates cxcr4-mediated signaling in neural progenitor cells.

"We demonstrate that hCD4-primed gp 120IIIB interacts with CXCR4 receptors expressed by postnatal mouse neural progenitor cells and elicits robust Ca2+ signals. The chemokine SDF-1 acted as a chemoattractant and a mitogenic stimulus for these neural progenitor cells," scientists in the United States report.

"Although hCD4/gp120 was not able to produce chemoattraction or increase proliferation, it completely blocked the ability of SDF-1 to produce these effects.

"Thus, gp120 can act both as an agonist and de facto antagonist of CXCR4-mediated signaling in...

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Source: Blood Weekly (2005-06-16)

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