Alzheimer Disease

Beta-site specific intrabodies prevents generation of Alzheimer A beta peptide

Published in Blood Weekly, June 16th, 2005

Beta-site specific intrabodies prevents generation of Alzheimer's A beta peptide.

According to a recent report published in the Journal of Cell Biology, "Endoproteolysis of the beta-amyloid precursor protein (APP) by beta- and gamma-secretases generates the toxic amyloid beta-peptide (A beta), which accumulates in the brain of Alzheimer's disease (AD) patients.

"Here, we established a novel approach to regulate production of A beta based on intracellular expression of single chain antibodies (intrabodies) raised to an epitope adjacent to the beta-secretase cleavage site of human APP."

"The intrabodies rapidly associated,...

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Source: Blood Weekly (2005-06-16)

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