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Mycobacterium Tuberculosis

Modified immunohistological staining detects Ziehl-Neelsen-negative MTB

Published in Blood Weekly, June 30th, 2005

Modified immunohistological staining detects Ziehl-Neelsen-negative Mycobacterium tuberculosis.

According to recent research published in the Journal of Pathology, "The diagnosis of mycobacterial infection depends on the Ziehl-Neelsen (ZN) stain, which detects mycobacteria because of their characteristic acid-fast cell wall composition and structure.

"The histological diagnosis of tuberculosis (TB) comprises various aspects: (1) sensitive detection of mycobacteria; (2) precise localization of mycobacteria in the context of granulomatous lesions; (3) 'staging' of disease according to mycobacterial spread and granulomatous tissue...

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