Septicemia

Heme oxygenase studied, effects of early expression in leukocytes reported

Published in Blood Weekly, June 30th, 2005

According to recent research from Taiwan, early expression of heme oxygenase-1 in leukocytes correlates negatively with oxidative stress and predicts hepatic and renal dysfunction at late stage of sepsis.

"Oxidative stress triggered by septic insult may be the major cause of multiple organ dysfunction syndrome (MODS) in intensive care unit patients. The inducible form of heme oxygenase-1 (HO-1) can be induced by cytokines, lipopolysaccharicle, and reactive oxygen species during sepsis.

"These facts raise the question of whether the expression of HO-1 in leukocytes can indicate the level of oxidative stress of multiple organs in sepsis," wrote H.C....

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Source: Blood Weekly (2005-06-30)

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