Published in Blood Weekly, June 30th, 2005
"To date, all human embryonic stem cells (hESCs) available for research require unidentified soluble factors secreted from feeder layers to maintain the undifferentiated state and pluripotency.
"Activation of STAT3 by leukemia inhibitory factor is required to maintain 'stemness' in mouse embryonic stem cells, but not in hESCs, suggesting the existence of alternate signaling pathways for self-renewal and pluripotency in human cells," wrote investigators in the United States.
"Here we show that activin A is secreted by mouse embryonic feeder layers...
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