Oncology
Agents targeting KIT exon 8 mutations may treat core-binding factor leukemia
Published in Blood Weekly, July 7th, 2005
According to a study from Germany, "KIT exon 8 mutations are located in the extracellular portion of the receptor and are strongly associated with core-binding factor (CBF)-acute myeloid leukemia (AML). To characterize the functional role of these mutants, we analyzed the pro-proliferative and antiapoptotic potential of 3 KIT exon 8 mutations in interleukin 3 (IL-3)-dependent Ba/F3 cells."
"All KIT exon 8 mutants induced receptor hyperactivation in response to stem cell factor (SCF) stimulation in terms of proliferation and resistance toward apoptotic cell death. A...
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Source: Blood Weekly (2005-07-07)
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