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HIV/AIDS Diagnostics

HIV infection affects uPAR release in whole-blood cultures

Published in Blood Weekly, July 7th, 2005

HIV infection affects urokinase-type plasminogen activator receptor release in whole-blood cultures.

"The blood levels of the soluble forms of the urokinase receptor (suPAR) are increased in human immunodeficiency virus (HIV)-1-infected patients. This study investigated whether the release of urokinase-type plasminogen activator receptor (uPAR) in whole-blood cultures was affected by HIV infection," scientists writing in the Scandinavian Journal of Immunology report.

"The release of different uPAR forms in whole-blood cultures incubated 24 hours with or without phytohemagglutinin and lipopolysaccharide was analyzed in 47 HIV patients and 19...

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