Avian Sarcoma Virus
Daxx interacts with ASV integrase and viral DNA to repress viral transcription
Published in Blood Weekly, July 14th, 2005
"The cellular protein Daxx was identified as an interactor with avian sarcoma virus (ASV) integrase (IN) in a yeast two-hybrid screen. After infection, Daxx-IN interactions were detected by coinummoprecipitation," scientists writing in the Journal of Virology report.
"An association between Daxx and viral DNA, likely mediated by IN, was also detected by chromatin immunoprecipitation. Daxx was not required for early events in ASV replication, including integration, as Daxx-null cells were transduced as efficiently as Daxx-expressing cells.
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Source: Blood Weekly (2005-07-14)
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