HIV/AIDS Drug Development

IL-4 antisense DNA inhibits pathogenic simian HIV replication in macaques

Published in Blood Weekly, July 21st, 2005

Interleukin-4 antisense DNA inhibits pathogenic simian HIV replication in macaques.

"Interleukin-4 is implicated in the pathogenesis of HIV-induced AIDS and causes enhancement of replication of virus strains that use the CXCR4 (X4) coreceptor. In this study, we explored the effects of interieukin-4 (IL-4) antisense (AS) DNA on replication of X4, simian human immunodeficiency viruses, SHIVKU-2 and SHIV89.6P," scientists in the United States report.

"AS IL-4 oligomer caused inhibition of virus replication in cultures of CD4+ T cells and macrophages derived from macaques. Plasmid expressing AS IL-4 DNA was also effective in abrogating virus replication...

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Source: Blood Weekly (2005-07-21)

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