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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . July 28th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Banking - Quality issues found in banked umbilical cord blood stem cells for transplant

Cryopreservation - Cryopreservation protocol developed to store 3-D bioartificial liver device

Hemophilia Therapy - Self-regulating lentiviral vector expresses human factor IX in vivo

Stem Cell Transplantation - Cultured BM cells can act as substitute for autograft or BMP in spine fusion

Umbilical Cord Blood Banking - Red blood cell depletion systems compared for cell recovery and RBC reduction

Acintobacter Baumannii -  A. baumannii outbreak caused by bla(OXA-21) determinant

Adenovirus - Adenovirus DNA detected by SYBR Green real-time PCR assay

Anemia - U.S. FDA approves IV therapy for iron deficiency anemia in pre-dialysis patients

Angiology - Reports advance knowledge in angiology research

Atherosclerosis - Novel blood test measuring oxidized fats is heart disease indicator

Avian Influenza - New avian influenza genotype present during the 2003-04 Asian bird flu outbreaks

HIV/AIDS Pathogenesis - Researchers' findings advance HIV/AIDS pathogenesis research

Awards - Sensation 64 CT system wins gold in 2005 Medical Design of Excellence Award

Bacteriology - Outcome of early-onset neonatal sepsis tied to bacterial genus

Bioartificial Liver - Microfabricated grooved substrate is platform for bioartificial liver reactors

Biomedical Engineering - Matrix molecules allow cells to create cardiovascular tissues

Biomedical Engineering - R&D collaboration with U of South Australia to focus on biopharmaceuticals

Bioterrorism - Antibiotic nonadherence is a concern for future bioterrorist events

HIV/AIDS Pathogenesis - Studies add new findings to HIV/AIDS pathogenesis body of knowledge

Blood Safety - Filtrations company and Fresenius Kabi AG partner to reduce prions

Blood Safety - Multitransfused thalassemic children show a risk for acquiring hepatitis C

Blood Safety - New advances in prion removal filter reported

Breast Cancer - New findings in the area of breast cancer described

Breast Cancer - Reovirus may be used as a purging modality for breast cancer during ASCT

Brucellosis - Tc-99m HIG scintigraphy helps diagnose osteoarticular involvement in brucellosis

Leukemia - Researchers provide details of new studies and findings in the area of leukemia

Business Update - Diagnostic equipment company awarded Premier contract for new ultrasound system

Business Update - Global Med sub signs nationwide contract with Nigeria

Cancer Therapy - Alliance to accelerate clinical development and commercialization of Ceflatonin

Cancer Therapy - Antibodies to angiogenic protein staunch murine acute myeloid leukemia

Candida Albicans - N-cadherin mediates endocytosis of Candida albicans by endothelial cells

Cardiac Myxoma - Caspase-3-dependent apoptosis in cardiac myxoma not associated with HPV or EBV

Leukemia - Researchers publish new studies and findings in the area of leukemia

Cerebral Embolism - Patients with AF and dense SEC at high risk for cerebral embolism

Childhood Cancer - Cancer related to distance from high voltage power lines in England and Wales

Childhood Cancer - Childhood cancer survival trends in Europe tracked

Childhood Cancer - Day care in infancy reduced risk of childhood acute lymphoblastic leukemia

Classical Swine Fever - U.S. classical swine fever isolates closely related to South American isolates

Clinical Trials - Clinical study of Aurora kinase inhibitor in hematologic cancers initiated

Tissue Engineering - Researchers' findings advance tissue engineering research

Clinical Trials - Recombinant human thrombin clinical trial results presented at meeting

Collaborations - Collaborative stem cell partnership announced in New Jersey

Coronary Artery Bypass - Cardiopulmonary bypass linked to post-CABG aspirin resistance

Coronary Artery Bypass - Perioperative RBC transfusion linked to heightened mortality risk

Corynebacterium Glutamicum - Ethambutol elicits L-glutamate efflux of Corynebacterium glutamicum

Critical Care - The hidden dangers of hospitals exposed

Crohn Disease -  Mycobacterium avium ssp. paratuberculosis may be implicated in Crohn disease

Dengue Virus - Lineage extinction/replacement in dengue 1 populations due to stochastic events

Diagnostics - Diagnostic usefulness of aberrant CD22 expression assessed

Drug Delivery - First patient receives TRT with Benephit Delta Infusion System

Drug Resistance - BLM helicase triggers leukemia cell resistance to cisplatin

Embryonic Stem Cell Research - Embryonic SCs give rise to mature gonadotrope-like cells in embryoid bodies

Embryonic Stem Cell Research - Embryonic stem cell line expressing EGFP established

Embryonic Stem Cell Research - TGF-beta 2 enhances cardiac myocyte differentiation from embryonic stem cells

Enterohemorrhagic Escherichia Coli - EC O157 acquired through indirect contact with farm environment

Environmental Ethics - Genetically modified insect vectors require examination

Escherichia Coli 0157:H7 Outbreak -  E. coli O157:H7 colitis outbreak associated with unpasteurized gouda cheese

Gastric Cancer - Gastric cancer may originate from circulating bone marrow-derived stem cells

Gastric Cancer - Postoperative detection of gastric cancer cells related to risk of recurrence

Generic Drugs - U.S. FDA grants tentative approval of generic oral blood-glucose-lowering drug

Genetics & Genomics - Company introduces new globin-reduction service

Gonorrhea - Prolyliminopeptidase-negative N. gonorrhoeae strain circulating in Denmark

Grants - U.S. NIH grants awarded to 9 research centers for molecular libraries initiative

HIV/AIDS Coinfection -  Pneumocystis jirovecii genotypes vary in HIV-infected patients in Thailand

HIV/AIDS Coinfection - GB virus C prevalence lower in HIV-infected children than in coinfected adults

HIV/AIDS Coinfection - Routine syphilis screening increases detection in HIV-infected patients

HIV/AIDS Drug Use - Cocaine upregulates DC-SIGN expression on dendritic cells in HIV infection

HIV/AIDS HAART - Improvement of virologic response to HAART due to increased adherence

HIV/AIDS Healthcare - Satellite pharmacy at HIV clinic improves physician-pharmacist interaction

HIV/AIDS Mental Health - HIV-infected patients with history of mental trauma report greater physical pain

HIV/AIDS Pathogenesis - Codon volatility does not reflect selective pressure on HIV-1 genome

HIV/AIDS Pathogenesis - Findings advance knowledge in HIV/AIDS pathogenesis research

HIV/AIDS Pathogenesis - Functional genomic relationships HIV-1 disease revealed

HIV/AIDS Pathogenesis - PAR-2 induction by neuroinflammation prevents neural death during HIV infection

HIV/AIDS Pathogenesis - RNA helicase DDX1 involved in restricted HIV-1 Rev function in astrocytes

HIV/AIDS Pneumococcal Vaccine - HIV-infected children have poorer qualitative antibody responses to PnCV

HIV/AIDS Prevention - Branded advertising campaign increases condom use in Tanzania

HIV/AIDS Prevention - Some sexual history questions lacking in sexually transmitted infection clinics

HIV/AIDS Quality-of-Life - HIV-related neurological syndromes reduce health-related quality of life

HIV/AIDS Risk Factors - 2- to 3-fold risk increase of acquiring HIV-1 infection among persons with STDs

HIV/AIDS Transmission - DC-SIGNR is a cofactor in sexual HIV-1 transmission

HIV/AIDS Transmission - Greater prevalence of HIV infections heterosexually-acquired in the U.K.

HIV/AIDS Viremia - Low-level viremia not uncommon during very early period of primary HIV infection

HIV/AIDS-Related Hyperlipidemia - Atazanavir switch improves metabolic disorders in hyperlipidemic HIV patients

HIV/AIDS-Related Infection - HLA-DQB*0402/DRBI*08 risk factor for developing AIDS-toxoplasmic encephalitis

HIV/AIDS-Related Lipoatrophy - Resistin levels decrease after rosiglitazone in HIV patients with lipoatrophy

HIV/Tuberculosis Coinfection - T cell decrease in HIV/TB coinfection leads to marked cytokine reduction

Healing - Wound closure modeled, acceleration after prior injury demonstrated

Heart Failure - Heart failure patients sought for study evaluating implantable pulse generator

Hematologic Disease - Phase I study of 506U78 for refractory hematologic malignancies conducted

Hematology - Japanese laboratory testing company selects new hematology testing system

Hematopoiesis - Podocalyxin is CD34-related marker of HSCs and embryonic erythroid cells

Hematopoiesis - Researchers describe findings in hematopoiesis studies

Hematopoietic Cells - Colony-stimulating factor isoforms studied, hematopoietic cell effects defined

Hemodialysis - Replacement of epoetin alfa with darbepoetin alfa safe, cost-effective

Hodgkin Disease - SHIELD program officially launched

Hodgkin Disease - The value of CT and MR imaging in Hodgkin disease weighed

Human Papillomavirus - HPV 63 targets keratinocytes in or around eccrine ducts in plantar skin

Human Papillomavirus - HPV DNA methylation helps diagnose emergence of a population of tumor cells

Leukemia - Findings in leukemia provide new insights

Leukemia - Maternal exposure to occupational solvents not linked to childhood leukemia

Marketing - New Jerseay biotechnoloogy company selects advertising agency

Medical Devices - Aortic mini-root-containing valves studied, endothelial seeding described

Methicillin-Resistant Staphylococcus Aureus - Screening program helps prevent hospital-acquired MRSA infections

Methicillin-Resistant Staphylococcus Aureus - Sequence types 8 and 80 predominate community-acquired MRSA in Norway

Multipotent Stem Cells - Multipotent stem cells isolated from adult olfactory mucosa

Mycobacterium Avium -  M. avium isolation method from milk tank improved

Mycobacterium Avium - Real-time PCR detects M. avium subsp paratuberculosis in water & milk

Mycobacterium Tuberculosis -  M. tuberculosis PDT is monofunctional and nonfusion protein

Mycobacterium Tuberculosis -  Mycobacterium tuberculosis strains possess functional cellulases

Mycobacterium Tuberculosis - ESAT-6 may contribute to macrophage activation in tuberculosis

Mycobacterium Tuberculosis - ESAT-6/CFP-10 fusion protein and peptides used for optimal MTB diagnosis

Mycobacterium Tuberculosis - GTP-binding/synergy loop domain mutations of MTB ftsZ compromise its function

Mycobacterium Tuberculosis - IdeR binding sites in sequences of all M. tuberculosis ORFs identified

Mycobacterium Tuberculosis - Monoacylated MDP confers TLR2/TLR4 activation on dendritic cells

Neural Stem Cell Research - Enriched environment increases neurogenesis in subventricular zone after stroke

Neural Stem Cell Transplantation - Lineage-restricted neural SCs differentiate after transplant to injured spine

Non-Hodgkin Lymphoma - HUMAX-CD20 induces clinical response in NHL at all dose levels, company reports

Norovirus Transmission - Person-to-person spread the most important norovirus transmission route

Nosocomial Infections - Digestive endoscopy transmits hepatitis C infection infrequently

Nosocomial Infections - Preoperative skin prep antiseptic now available in tint

Obesity - Choice/availability of take-out food not related to obesity prevalence

Pediatric Oncology - Pediatric and adult leukemia cells bear distinctly different properties

Personnel - Timothy M. Mayleben elected to bioscience company board of directors

Plague - Functions of differentially expressed proteins ID'd for Yersinia species

Platelets - Glycoproteins and von Willebrand factor studied, bond kinetics clarified

Prostate Cancer - No serological evidence of association between prostate cancer and HSV2/HSV8

RNA Research - Preliminary microRNA expression in mouse stem cells presented at conference

SARS Coronavirus - Researchers report details of new studies and findings in the area of SARS coronavirus

Sexually Transmitted Infection - High herpes simplex virus-2 and syphilis seroprevalence among female drug users

Stem Cell Research - Australian officials launch new human embryonic stem cell line, drives network

Stem Cell Research - BRCA2 deficiency in small intestine leads to spontaneous stem cell deletion

Stem Cell Research - Company provides update on hESC at stem-cell meeting

Stem Cell Research - EDNRB or KIT signaling needed for maintenance/survival of melanocyte precursors

Stem Cell Research - GCSF & GMCSF have differential effects on neutrophil survival and function

Stem Cell Research - Long-term survival of blood stem cells reported in cloning and stem cells

Stem Cell Research - Molecular markers distinguish bone marrow mesenchymal SCs from fibroblasts

Stem Cell Research - Neural stem cells isolated from postnatal cerebellum

Stem Cell Research - Neurturin augments non-neuronal cell numbers via increased cell proliferation

Stem Cell Research - Peripheral blood cell fractions spawn endothelial progenitor cells

Stem Cell Research - Zac1 expressed in stem cells of neuroectoderm and mesoderm during embryogenesis

Stem Cell Transplantation - IL-6/TNF-alpha polymorphisms identifies risk of unsuccessful limbic SC graft

Streptococcus Pyogenes - Different strains may circulate simultaneously during S. pyogenes outbreak

Tissue Engineering - Researchers' data advance tissue engineering research

Tissue Engineering - Respiratory epithelial cells may be used for tracheal tissue engineering

Tissue Engineering - Rotary culture enhances preosteoblast aggregation and mineralization

Tissue Engineering - Tissue-engineered artificial bile duct resembles native bile duct

Tissue Engineering - Umbilical vein scaffold developed for cardiovascular tissue engineering

Transplant Medicine - Basiliximab may reduce incidence of acute organ rejection in lung transplants

Transplant Medicine - Enrollment in trial of new fibrin sealant system for liver transplant complete

Transplant Medicine - Repeated pulse therapy increases graft loss in HCV-positive liver recipients

Transplantation Medicine - PaO2 <250mmHg is not a definite contraindication for lung transplantation

Tuberculosis - Antimycobacterial therapy associated with shift toward predominant Th1 phenotype

Tuberculosis - Biochemical changes associated with antituberculosis drugs

Tuberculosis - Cattle movements predict bovine tuberculosis occurrence in Great Britain

Tuberculosis - Tuberculosis diagnosis confirmed by PCR in prehistoric skeleton in Britain

Vancomycin-Resistant Enterococcus Faecium - Esp gene detected in all vancomycin-resistant E. faecium strains in Korea

Venous Ulcers - Final version of OrCel study protocol submitted to U.S.FDA

Yersinia Pestis - pgm locus plays role in Yersinia pestis adaptation to its environment

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