Mycobacterium Tuberculosis
ESAT-6 may contribute to macrophage activation in tuberculosis
Published in Blood Weekly, July 28th, 2005
"The influence of the 6 kDa early-secreted antigenic target (ESAT-6) of Mycobacterium tuberculosis on macrophage activation was investigated using J774 macrophage cell line. While without effect if applied alone, ESAT-6 in a dose-dependent manner enhanced nitric oxide (NO) release by IFN-gamma-stimulated J774 cells," researchers in India report.
"However," said the authors, "it completely failed to modulate NO production in J774 cells activated with E. coli lipopolysaccharide. The effect of ESAT-6 on NO synthesis in IFN-gamma-activated J774 cells was accompanied by...
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Source: Blood Weekly (2005-07-28)
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