Blood Weekly

Blood Transfusion - Pleckstrin examined, C domain structure and binding properties clarified

Bone Marrow Transplantation - Serious infection risk after pediatric UCBT comparable to unmanipulated BMT

Neural Stem Cell Research - Cryopreservation does not affect proliferation/multipotency of neural stem cells

Tissue Engineering - Cryopreserved endothelial cells suitable for vascular tissue engineering

Tissue Engineering - Semisynthetic "smart" materials promising as scaffolds for tissue engineering

Adverse Drug Reaction - Report describes commonly used meds that worsen insulin resistance

Allergy & Immunology - T cell kinase examined, mast cell and allergic regulation revealed

Angiology - Television ad campaign directed at patients with varicose veins

Angiology - von Willebrand factor examined, transient platelet adhesion clarified

Angiology - von Willebrand factor studied, role in platelet adhesion to fibrinogen shown

HIV/AIDS Pathogenesis - Reports describe recent advances in HIV/AIDS pathogenesis research

Anthrax - Assay detects antibody-mediated neutralization of anthrax protective antigen

Antifungals -  C. albicans zinc cluster protein Upc2p confers resistance to antifungal drug

Atherosclerosis - Defective clotting factor clears arteries

Awards - U.K. business development agency wins best practices award for stem cell policy

Bleomycin - Bleomycin used to treat complicated hemangiomas

Bovine Herpesvirus - CD11b+ PBLs main target cell populations in blood for bovine herpesvirus 4

Transplant Medicine - New findings in the area of transplant medicine detailed

Breast Cancer - Nuclear heparanase emergence induces mammary cancer cell differentiation

Business Update - Biotest wins bid for blood group systems

Business Update - Geisinger Health System adopts biospecimen management system

Business Update - Transfer of marketing rights to blood-clotting drug to sanofi Japan announced

Cancer Detection - The ANN/TM-GTP index accurately predicts recurrent liver cancer

Cancer Survivors - Fear of recurrence, sense of coherence, and PTSD in cancer survivors assessed

Transplant Medicine - New research in the area of transplant medicine detailed

Cancer Therapy - Bendamustine-plus-rituximab is an effective lymphoma treatment

Cardiac Transplantation - Ischemic preconditioning of recipient decreases heart transplant injury

Cardiology - Integrin-linked kinase protects endothelial cells and encourages vessel growth

Cardiology - Long-term coronary heart disease study with niacin tablets, simvastatin begun

Cell Biology - Biological activity flourishes despite apoptotic induction in stem cells

Cell Development - Colony-stimulating factor-1 examined, diverse isoform effects noted

Chronic Hepatitis B - Female gender and low platelet counts favor hepatitis B response to lamivudine

Chronic Lymphocytic Leukemia - NDA submitted for Genasense in patients with relapsed or refractory CLL

Coronary Artery Bypass - Hemostatic activation characterized during CPB with bivalirudin

Coronary Artery Disease - Low numbers of endothelial progenitor cells predict heart disease progression

Creutzfeldt-Jakob Disease - Purifications company releases research on prior reduction filter system

Dendritic Cell Sarcoma - Expression profiles of dendritic cell sarcoma similar to hematopoietic SCs

Diabetes Complications - Cord blood-derived progenitor cells reverse diabetic neuropathy

Diagnostics - Brain natriuretic peptide monitors cardiac surgery patients for complications

Drug Development - Genetics-focused company updates drug development programs at investor event

Drug Resistance - Three U.K. research companies join forces to tackle antibiotic drug resistance

Embryonic Stem Cell Research - Cardiomyocytes obtained from embryonic stem cells by inhibition of BMP signaling

Embryonic Stem Cell Research - ESC gene expression profiles correlated with functional measures of pluripotency

Embryonic Stem Cell Research - ESC progeny respond appropriately to host cues in subventricular zone

Embryonic Stem Cell Research - Stable mixed chimerism induced by ESCs requires functional Fas/FasL engagement

Embryonic Stem Cell Research - Zfp-57 is downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells

Emerging Pathogen - Primate T-lymphotropic viruses reported in African bushmeat hunters

End Stage Kidney Disease - Hepatitis B vaccine raises antibody in HIV-infected hemodialysis patients

Endometrial Cancer - Epigenetically masked tumor suppressor genes identified in endometrial cancer

Estrogen - Estrogen regulates CCR gene expression and function in T lymphocytes

Fitness & Wellness - Foot and ankle surgeons group warns of infection risks from foot puncture wounds

Fungal Infections - Antifungal peptide harvested from haricot beans

Gender Medicine - Article treats influence of sex and gender on musculoskeletal health

Gene Research - Cellular promoters prolong transgene expression in progenitor cells

Genetics - Genotyping may be necessary when stratifying bleeding risk after cardiac surgery

HIV/AIDS & Tuberculosis Coinfection - HIV infection may not be associated with drug resistant tuberculosis

HIV/AIDS Coinfection - Asymptomatic syphilis detected more frequently in HIV patients

HIV/AIDS Diagnostics - MRSI used to assess neuronal function in HIV-1-associated dementia

HIV/AIDS Drug Adherence - Stavudine adherence improves with switch to once-daily dosing

HIV/AIDS Drug Development - Directed evolution creates new PDZ domains for HIV protease activity detection

HIV/AIDS Drug Development - Human cell factor(s) inhibit HIV reverse transcriptase

HIV/AIDS Drug Development - Oximinoarylsulfonamides inhibit HIV protease

HIV/AIDS Drug Development - South African medicinal plant extracts inhibit HIV-1 RT/integrase

HIV/AIDS Drug Resistance - FHIV-1 L89M mutation is high genetic barrier to accumulation of L90M mutations

HIV/AIDS Drug Side Effect - HIV medications impact speech and hearing

HIV/AIDS Drug Side Effect - High OPG levels may protect against bone resorption in HIV patients on HAART

HIV/AIDS Economics - Economic implications of AIDS may be serious for India in the future

HIV/AIDS Epidemiology - High HIV transmission rates in Africa due to high rates of other untreated STIs

HIV/AIDS HAART - Abacavir + efavirenz effective PI alternative in heavily pretreated HIV patients

HIV/AIDS HAART - HAART initiation will alter the biology and evolution of HIV/AIDS in India

HIV/AIDS HAART - Improved response to HAART may also be attributable to adherence/tolerability

HIV/AIDS HAART - Low-cost assays can monitor HAART patients in developing countries

HIV/AIDS Heart Disease - Ritonavir impairs vasomotor function/reduces coronary artery eNOS expression

HIV/AIDS Pathogenesis - APOBEC3G ubiquitination by HIV-1 Vif-BC-Cul5 is essential for Vif function

HIV/AIDS Pathogenesis - Data advance knowledge in HIV/AIDS pathogenesis research

HIV/AIDS Pathogenesis - Fitness differences of 2 HIV-1 isolates related to cell binding/entry efficacy

HIV/AIDS Pathogenesis - HIV Nef establishes superinfection immunity by downregulating CCR5 and CD4

HIV/AIDS Pathogenesis - HIV Nef protein promotes survival of infected cells

HIV/AIDS Pathogenesis - HIV without polypurine tract mutations can replicate at low level

HIV/AIDS Pathogenesis - HIV-1 Tat concomitantly downregulates caspase-10/upregulates c-FLIP in T cells

HIV/AIDS Pathogenesis - Mutant Vif proteins incapable of modulating viral infectivity

HIV/AIDS Postexposure Prophylaxis - TDF-3TC-d4T most tolerated regimen for nonoccupational postexposure prophylaxis

HIV/AIDS Prevention - New findings in HIV/AIDS prevention described

HIV/AIDS Prognosis - Baseline CD4 count strongest predictor of short-term disease progression in Asia

HIV/AIDS Prognostics - CD4+ T cell count monitors HIV progression & antiretroviral therapy

HIV/AIDS Prognostics - CD4:CD8 ratio or CD4 percentage determines risk of progression with HAART

HIV/AIDS Prognostics - CX(3)CR1 polymorphisms predict HIV-1 disease progression in children

HIV/AIDS Quality-of-Life - HIV-related neurological syndromes reduce health-related quality-of-life

HIV/AIDS Research -  D. melanogaster complementary system to study HIV-1-related genes/proteins

HIV/AIDS Screening - Rapid HIV testing strategies feasible in under equipped laboratories