Leukemogenesis
Myeloid leukemia factor 1 is a critical regulator of p53
Published in Blood Weekly, August 4th, 2005
According to a recently published report from Japan, "Myeloid leukemia factor 1 (MLF1) was first identified as the leukemic fusion protein NPM-MLF1 generated by the t(3;5)(q25.1;q34) chromosomal translocation.
"Although MLF1 expresses normally in a variety of tissues including hematopoietic stem cells and the overexpression of MLF1 correlates with malignant transformation in human cancer, little is known about how MLF1 is involved in the regulation of cell growth."
"Here we show that MLF1 is a negative regulator of cell cycle progression functioning upstream of the tumor...
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Source: Blood Weekly (2005-08-04)
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