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Tissue Engineering

Semisynthetic "smart" materials promising as scaffolds for tissue engineering

Published in Blood Weekly, August 4th, 2005

Semisynthetic "smart" materials are promising as scaffolds for tissue engineering.

"In this review, we focused our attention on the more important natural extracellular matrix (ECM) molecules (collagen and fibrin), employed as cellular scaffolds for tissue engineering and on a class of semisynthetic materials made from the fusion of specific oligopeptide sequences, showing biological activities, with synthetic materials.

"In particular, these new 'intelligent' scaffolds may contain oligopeptide cleaving sequences specific for matrix metalloproteinases (MMPs), integrin binding domains, growth factors, antithrombin sequences, plasmin degradation sites,...

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