HIV/AIDS Pathogenesis
HIV without polypurine tract mutations can replicate at low level
Published in Blood Weekly, August 4th, 2005
"We introduced polypurine tract (PPT) mutations, which we had previously tested in an in vitro assay, into the viral clone NL4-3KFSDelta nef. Each mutant was tested for single-round infectivity and virion production," scientists in the United States report.
"All of the PPT mutations had an effect on replication; however," wrote L.R. Miles and colleagues at Morehouse School of Medicine in Atlanta, "mutation of the 5' end appeared to have less of an effect on infectivity than mutation of the 3' end of the PPT sequence.
"Curiously, a mutation in which the entire PPT...
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Source: Blood Weekly (2005-08-04)
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