Kaposi Sarcoma-Associated Herpesvirus

Exonuclease and host shutoff functions of KSHV SOX are genetically separable

Published in Blood Weekly, August 11th, 2005

The exonuclease and host shutoff functions of the Kaposi's sarcoma-associated herpesvirus SOX protein are genetically separable.

"The Kaposi's sarcoma-associated herpesvirus (KSHV) SOX protein, encoded by ORF37, promotes shutoff of host cell gene expression during lytic viral replication by dramatically impairing mRNA accumulation.

"SOX is the KSHV homolog of the alkaline exonuclease of other herpesviruses, which has been shown to function as a DNase involved in processing and packaging the viral genome," scientists in the United States report.

"Although the exonuclease activity of these proteins is widely conserved across all...

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Source: Blood Weekly (2005-08-11)

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