Stem Cell Research

TGF-beta-1-2-3 & IFN-beta induce hepatocyte growth factor secretion by microglia

Published in Blood Weekly, August 25th, 2005

TGF-beta-1-2-3 and interferon-beta induce hepatocyte growth factor secretion by microglia.

According to a study from Switzerland, "In acute experimental autoimmune encephalomyelitis (EAE), demyelination is induced by myelin-specific CD4+ T lymphocytes and myelin-specific antibodies.

"Recovery from the disease is initiated by cytokines which suppress T cell expansion and the production of myelin-toxic molecules by macrophages. Th2/3 cell-derived signals may also be involved in central nervous system (CNS) repair."

"Remyelination is thought to be initiated by the recruitment and differentiation of oligodendrocyte precursor cells...

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Source: Blood Weekly (2005-08-25)

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