Skin Allograft

Persistent BM Sca-1+ cell contact with graft alloantigen may prolong survival

Published in Blood Weekly, September 1st, 2005

Persistent bone marrow Sca-1+ cell contact with graft alloantigen may prolong allograft survival.

According to a study from Canada, "Many studies indicate that tolerance induction is much more dependent on the maturation status of lymphocytes than the age of the animal.

"We hypothesized that direct persistent contact of bone marrow stem cells with graft alloantigen will result in tolerance to that antigen in the adult animal."

"Severe combined immunodeficient mice (CB-17-Scid, H-2b) were reconstituted with isogeneic bone marrow stem cell antigen-1 (Sea-1)-positive cells and grafted with fetal thymus (BMSC-T), followed by...

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Source: Blood Weekly (2005-09-01)

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