Bioreactor

Monoclonal antibodies continually/efficiently produced in packed-bed bioreactor

Published in Blood Weekly, September 1st, 2005

Monoclonal antibodies are continually and efficiently produced in a packed-bed bioreactor.

"In the present study the growth and MAb (monoclonal antibody) production of a mouse x mouse hybridoma cell producing antidigoxin MAb was evaluated. The hybridoma cells entrapped within the support matrix Fibra-Cel were cultured in batch and continuous mode following special protocols," scientists in Iran report.

"Cell-culture studies were performed in a 1-litre spinner basket containing 3 g center dot liter(-1) support matrix. Batch culture was operated with the cell density of 42x10⁶ cells. During the 7 days of culture, the medium was sampled daily...

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Source: Blood Weekly (2005-09-01)

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