Cardiac Transplantation

Caspase-3 inhibition prevents graft coronary artery disease in transplantation

Published in Blood Weekly, September 1st, 2005

Early inhibition of caspase-3 activity lessens the development of graft coronary artery disease.

According to researchers in the United States, "The role of apoptosis in the development of graft coronary artery disease (GCAD) is poorly understood. We have previously shown that early overexpression of the antiapoptotic protein Bcl-2 lessens the development of GCAD. We hypothesized that early inhibition of apoptosis with a caspase-3 inhibitor would also lessen the development of GCAD."

L.B. Balsam and colleagues of Stanford University explained, "Heterotopic heart transplantation was performed in 4 groups of rats. Donor hearts were pretreated with 50...

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Source: Blood Weekly (2005-09-01)

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