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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . September 8th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Safety - System removes transmissible spongiform encephalopathy during plasma separation

Cell Therapy - Mesenchymal stem cells support the expansion of irradiated CD34+ cells

Hemophilia A - Trial of investigational albumin-free recombinant drug for hemophilia A begun

Hemophilia Therapy - Guidelines for recombinant activated factor VII in bleeding released

Tissue Engineering - Vascularized bone engineered from osteoblast-polyglycolic acid scaffold

Acinetobacter Baumannii - Risk factors identified for carbapenem-resistant A. baumannii outbreak

Acute Myeloid Leukemia - AML bearing cytoplasmic nucleophosmin showed distinct gene expression profile

Acute Myeloid Leukemia - Antiangiogenic treatment with endostatin successfully fights AML

Aging - Genetic factors play role in successful aging

Anemia - Long-term outcome of treatment of anemia with erythropoietin and G-CSF assessed

Hematology - Studies advance knowledge in hematology research

Anemia - Researchers discover new route to hemoglobin synthesis

Angiology - Quantum dots spectrally distinguished tumor pathophysiology

Angiology - Researchers provide details of new studies and findings in the area of angiology

Anthrax - Studies advance knowledge in anthrax research

Antioxidant - Flavonoids may promote cell survival as potent antioxidants

Apoptosis - Death receptors/Fas/TRAIL receptors involved in osteoclast apoptosis

Leukemia - Findings advance knowledge in leukemia research

Apoptosis - Novel polysaccharide induced apoptosis in HL-60 cells

Arteriosclerosis - Prothymosin alpha linked to transplant arteriosclerosis

Atrial Fibrillation - Guidelines focus on postoperative atrial fibrillation

BK Virus - The role of BK virus in cancer and autoimmune disease continues to be debated

Bacterial Sepsis - Antimicrobial peptide WLBU2 has potential application against P. aeruginosa

Leukemia - Studies add new findings to leukemia body of knowledge

Benzene Exposure - Lymphotoxicity due to benzene not mediated through diminished thymus function

Benzene Toxicity - Advances in genotyping may elucidate toxic effects of benzene on stem cells

Blood Cancer - Society launches national education program for elderly blood cancer patients

Blood Transfusion - Transfusion-related acute lung injury and ICU reviewed

Bone Marrow - Dose of CsA prolonged relapse rate in childhood ALL after bone marrow transplant

Bone Marrow - Whole-body MRI of bone marrow performed

Bone Marrow Transplantation - NK-KIR transcript kinetics correlate with acute GVHD occurrence after ABMT

Breast Cancer - Reports add new data to breast cancer research

Business Update - Cord blood bank exceeds 100,000 client milestone

Business Update - Icagen reports second quarter 2005 financial results

Cancer Therapy - Data advance knowledge in cancer therapy research

Cancer Therapy - U.S. NIH awards grant for preclinical development of Talotrexin in combo therapy

Cardiac Ablation - Adapter was effective in epicardial RFA in a beating heart

Cardiac Transplantation - Caspase-3 inhibition may be useful strategy for preventing graft CAD

Cardiopulmonary Resuscitation - Stored wet-primed ECMO circuits maintain function for 2 weeks

Celiac Disease - PARP-1 is perpetrator in celiac disease

Circulation - CellTrack provides automated analysis of circulating cell behavior

Circulation - Raman-based assay measures microvascular oxygenation

Clinical Trials - Clinical trials of SCT in multiple sclerosis are currently premature

Complementary & Alternative Medicine - Garlic oil and DDB have a hepatoprotective effect while lowering plasma lipids

Congestive Heart Failure - Heart failure worsens with anemia, increases risk of death

Corneal Injury - Thymosin-beta 4 treats severe inflammation-mediated corneal injuries

Cryptococcus Neoformans -  G. mellonella moth used to study Cryptococcus neoformans pathogenesis

Dengue Fever - Dengue virus replication analyzed, nitric oxide-mediated suppression shown

Dengue Fever - Increasing Dengue hemorrhagic fever in Brazil not associated with new genotypes

Diabetes Epidemiology - Long-term sucrose-drinking causes increased body weight and glucose intolerance

Disease Associations - Chronic allograft nephropathy studied, rat model analyzed

Drug Development - Rv3806c-encoded enzyme is a target for the development of new tuberculosis drugs

Drug Resistance - Imipenem effective against tuberculosis in mice and humans

Embolism - Clinical outcome of patients with venous thromboembolism revealed

Endothelial Cell - Autologous endothelial cells mat be beneficial in treating vascular injury

Entamoeba Histolytica -  Entamoeba histolytica from same geographic region genetically diverse

Epstein-Barr Virus - CD8 cell epitopes specific for EBV immediate-early transactivator Rta identified

Finance - Hemodialysis products manufacturer reports 77% increase in sales

Fonconi Anemia - Hypoxia-reoxygenation induces premature senescence in Fanconi anemia BM cells

HIV Diagnostics - Rapid HIV diagnostic test eliminates human error

HIV/AIDS Bone Health - Bone mineral content of HIV-infected children comparable to healthy children

HIV/AIDS Drug Adherence - Complete HAART adherence crucial in maintaining virological response over time

HIV/AIDS Drug Development - Antifungal peptide from ground beans inhibitory toward tumor cells and HIV-1 RT

HIV/AIDS Drug Resistance - NRTI/NNRTI resistance more frequent than PI when resistant to 2-3 ARV classes

HIV/AIDS Drug Resistance - Studies add new findings to HIV/AIDS drug resistance body of knowledge

HIV/AIDS Drug Side Effect - Efavirenz diminishes antilipid efficacy of HMG-CoA reductase inhibitors

HIV/AIDS Encephalitis - E2F4 changes may contribute to altered neuronal morphology or survival in SIVE

HIV/AIDS Epidemiology - Consistent clade homogeneity of HIV strains circulating in Mozambique

HIV/AIDS Epidemiology - Epidemiologic method estimates orphan number as a result of AIDS/other causes

HIV/AIDS Neuropathology - Neuropathologies of HIV infection identified by forensic autopsy

HIV/AIDS Pathogenesis - Increased levels of anti-HspBP1 IgG are prevalent in HIV infected subjects

HIV/AIDS Pathogenesis - Researchers' data advance HIV/AIDS pathogenesis research

HIV/AIDS Risk Factors - SDF-1 3'A allele increases AIDS risk

HIV/AIDS Therapy - Vascular changes greater in HIV-infected children exposed to protease inhibitors

HIV/AIDS Tuberculosis Coinfection - Elevated cytokines contribute to continuous HIV viremia during TB coinfection

HIV/AIDS-Associated Arthritis - Arthritis causally related to HIV infection in children

HIV/AIDS-Associated Periodontal Disease - Active human cytomegalovirus reactivation triggers periodontal disease activity

HIV/AIDS-Related Cancer - Cancer survival improving in persons with HIV/AIDS

Healthcare Costs - Cost effectiveness policies hinder progress toward effective global TB control

Heart Failure - Walk test has limited use to assess changes in patients with severe HF

Hematology - Reports advance knowledge in hematology research

Hemophilia - Data for Advate confirm safety and efficacy in hemophilia A patients

Hemostasis - Researchers find link between low-density lipoprotein receptor and hemostasis

Hepatitis B Vaccine - HBV vaccine questionable in patients receiving lamividine post liver transplant

Hepatitis B Virus - Company announces end of patient dosing in HepeX-B hepatitis B phase II trial

Hepatitis C Virus - Donor age above 50 increases risk of recurrence after liver transplantation

Imaging - Technology successfully demonstrated CV circulation in 4-D

Immunotherapy - Data published about reversing the natural immune system aging provess

Infections - Shiga toxin assessed, role in up-regulation of tissue factor activity revealed

Influenza Epidemic - Timing of influenza and bird flu epidemics calculated

Information Technology - Hospital purchases transfusion management system

Ischemia - Hepatic ischemia reperfusion injury studied, kinase mediatory role revealed

Kaposi Sarcoma - HHV8 is a useful tool in confirming the diagnosis of cutaneous Kaposi sarcoma

Kaposi Sarcoma-Associated Herpesvirus - KSHV may be sexually transmitted among Cuban population

Kidney Disease - Study evaluates treatment for patients with anemia from chronic kidney disease

Kidney Failure - Researchers explore reasons for complications with kidney failure patients

Kidney Transplantation - Intrarenal resistance indices are associated with CV risk factors

Klebsiella Pneumoniae - Carbapenem-resistant K. pneumoniae rapidly spreading in New York City

Lead Poisoning - Biochemical markers of lead exposure in children identified

Legionellosis -  L. pneumonia infection caused by exposure to contaminated bath water

Leprosy - Leprosy diagnosis should be considered in patients who work/travel in tropics

Leukapheresis - Large-volume leukapheresis safe/effective in low-weight pediatric patients

Leukemia - AML patients with Down syndrome showed high cure rate with AML-BFM therapy

Leukemia - Data advance knowledge in leukemia research

Leukemia - Irradiation did not improve survival in ALL children with testicular disease

Leukemia - NPM1 and FLT3-ITD mutations detected by capillary electrophoresis

Leukemia - Podocalyxin's role as marker of blasts in acute leukemia reviewed

Leukemia - Risk of AML and MDS linked to adjuvant epirubicin for early breast cancer

Lung Cancer - C-erbB-2 not involved in first steps of lung carcinogenesis

Lupus Erythematosus - Antiendothelial cell antibodies from lupus patients do not induce apoptosis

Lymphopenia - Researchers investigate role of IL-6 in lymphopoiesis

Malaria - LANCL1 examined, recruitment during P. falciparum development clarified

Malaria - Potent inhibitors of malarial plasmepsin I and II synthesized

Medical Devices - Study results for device to treat brain vascular disorder reported at meeting

Medical Devices - U.S. FDA approval granted for Tango reagents

Microsurgery - Microvascular anastomosis may be performed in hyperfibrinogenemia

Multicomponent Apheresis Collection - Red cell apheresis may become the collection standard

Mycobacterium Avium - Identified M. avium gene affects invasion of intestinal epithelium

Mycobacterium Tuberculosis - Scanning electron microscopy analyzes aged Mycobacterium tuberculosis cells

Needle Stick Injury - Accidental blood exposures among healthcare workers in West Africa assessed

Neural Migration - Cell culture model used to investigate glial-guided neuronal migration

Neural Repair - Manipulating neurogenesis may be used to repair neural circuitry

Non-Hodgkin Lymphoma - Drinking alcohol may lower risk of non-Hodgkin lymphoma

Norovirus Outbreaks - Gastroenteritis outbreaks in Switzerland caused by noroviruses

Norovirus Outbreaks - Norovirus contamination found in oysters worldwide

Nosocomial Infections - Parasites underestimated in nosocomial diarrhea

Nosocomial Infections - Six Pennsylvania hospitals given grants to analyze hospital-acquired infections

Osteoclast Differentiation - Intracellular reactive oxygen species are signal mediators for differentiation

Patents - Patent application filed for Pher-O2 oxygen carrier

Peripheral Arterial Occlusion - Clinical trial data of chronic peripheral arterial occlusion treatment published

Pseudomonas Aeruginosa - Nonsterile cotton jersey causes surgical wound infections

Retrovirus - HIV mania is a marker for clinical deterioration in AIDS

SARS - Early centralization of infectious patients may reduce extent of epidemics

SARS - Infection control implemented in radiology department after SARS outbreak

SARS Outbreak - Protective measures begun during SARS outbreak reassures health care workers

Sepsis - Protein C examined, role as marker in diffuse secondary peritonitis revealed

Sepsis - Therapeutic potential of recombinant human antithrombin on sepsis presented

Sexual Risk Behaviors - Alcohol intoxication associated with sexual risk behaviors in migrants in China

Sexually Transmitted Diseases - Migration contributes significantly to spread of sexually transmitted infections

Skin Cancer - CD8+ and CD4+ lymphocytes contribute to immunosurveillance against skin cancer

Stem Cell Aging - Cell intrinsic alterations underlie hematopoietic stem cell aging

Stem Cell Research - Bone marrow-derived side population cells can contribute to respiratory tract

Stem Cell Research - Embryonic stem cell research explored from an Islamic perspective

Stem Cell Research - Fetal liver epithelial cells with high repopulation capacity characterized

Stem Cell Research - Galanin regulates stem cell proliferation/migration/differentiation

Stem Cell Research - Growth-stimulatory effects of androgens on hematopoietic stem cells are minimal

Stem Cell Research - MRI differentiates localized/widespread neural stem cell engraftment in the CNS

Stem Cell Research - NANOG expressed in fetal gonocytes/testicular carcinoma/germ cell tumors

Stem Cell Research - Natural killer T cells fully reprogrammed by a single-step nuclear transfer

Stem Cell Research - Neural stem cells potential source of oligodendrocytes for myelin repair

Stem Cell Research - Nonribosomal landscape in nucleolus revealed by stem cell protein nucleostemin

Stem Cell Research - Sox15 & Sox2 have differential roles in transcriptional control in embryonic SCs

Stem Cell Research - Transplanted bone marrow cells generate new brain cells

Stem Cell Research - Various methods developed to analyze chemokinetic and chemotactic cell migration

Stem Cell Transplantation - Bone marrow stromal cell transplantation improves

Stem Cell Transplantation - Peripheral blood SCs speed neutrophil/platelet engraftment in lymphoma patients

Stress-Induced Fibrinogen - IL-6 reactivity was an independent predictor of stress-induced fibrin formation

Tissue Engineering - Bioactive scaffold used to regenerate nucleus pulposus tissue

Tissue Engineering - Cell-bioceramic interactions characterized via enhanced GFP-labeled MSCs

Tissue Engineering - Ectopic bone formation associated with MSCs in resorbable ceramic

Tissue Engineering - N-acetylation controls cell adhesion and degradation of chitosan films

Tissue Engineering - Scaffold developed to guide nerve tissue regeneration after transection injury

Topical Microbicide - Topical penile microbicide wipe safe/effective at reducing STI-related bacteria

Transplant Medicine - Studies advance knowledge in transplant medicine research

Tuberculosis Risk Factors - Smoking may increase the risk of Mycobacterium tuberculosis infection

Tuberculosis Risk Factors - Tuberculosis risk after HAART initiation higher in patients with history of TB

Tuberculous Infection - Reactivated tuberculous infection becoming more prevalent after transplantation

Type 1 Diabetes - Researchers make "embryonic-like" stem cells from umbilical cord blood

Ventilator-Associated Bacterial Pneumonia - Rapid ventilator-associated bacterial pneumonia identification reduces mortality

Water-Pipe Smoking - Water-pipe smoking is an emerging health risk behavior

Yersinia - Bovine lactoferrin inhibits Yersinia-directed epithelial cell apoptosis

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