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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . September 15th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Safety - HTLV-I/II inactivated in blood products by photochemical inactivation

Pediatric Leukemia - Bloodstream infections occurred in children undergoing acute leukemia treatment

SARS-Coronavirus Inactivation - Solvent and detergent treatment completely inactivates SARS-coronavirus

Stem Cell Research - Cord blood CD4+CD25+ FOXP3+ T cells suppress antigen-specific T cell responses

Wound Healing - Human mesenchymal stem cells successfully improve skin-substitute wound healing

Acute Lymphoblastic Leukemia - Pediatric protocols yield better outcomes for young-adult ALL patients

Acute Myeloid Leukemia - Cyclin A1 expression predicts disease-free and overall survival in AML patients

Anemia - A better screening test for infant iron deficiency?

Angiology - Recent findings in angiology provide new insights

Angiology - Shipment of disposable thrombin processing device to Biomet subsidiary CFT begun

Angiology - Study found no correlation between platelet activation and angiographic severity

HIV/AIDS Pathogenesis - Researchers detail new studies and findings in the area of HIV/AIDS pathogenesis

Angiosarcoma - Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma

Antifungal Drugs - Caspofungin safe and effective antifungal agent

Antimicrobials - JNK pathway essential for normal antimicrobial peptide release in Drosophila

Apoptosis - Data advance knowledge in apoptosis research

Apoptosis - Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis

Aspergillosis - Aspergillosis outbreak occurred in ostrich flock in Turkey

Bactericidal Effect - HIF-1 alpha expression regulates the bactericidal capacity of phagocytes

Biflavonoid - Biflavonoid acted as inhibitor of DNA topoisomerases

Blood Supply - American Red Cross asks for help with blood shortage

Bone Resorption - Researchers looking forward to new bone inhibitor development for study and use

Botulism Vaccine - Botulinum neurotoxin heavy chain fragments formulated for vaccine development

Business & Finance - Hematolymphatics-focused company completes $17.3M financing

Candida Infection - Breakthrough Candida infections occurred in patients receiving voriconazole

Cardioprotection - Research in cardioprotection provides new insights

Cell Transplants - Early secondary cancer detection important in prolonging overall HSCT survival

Chronic Hemodialysis - Darbepoetin alfa treatment is safe and cost-effective

Clinical Trials - Aggregate results of phase 2 trials for recombinant human thrombin presented

Colonoscopy - Non-small bowel lesions detected by capsule endoscopy

Coronary Heart Disease - Patients with CHD have higher expression of HO-1 in heme oxygenase-1

Creutzfeldt-Jakob Disease - "Mad cow" proteins successfully detected in blood

Diagnostics - PCR-RFLP rapid & reliable for discriminating N. asteroids complex species

Drug Development - Marine compounds active against multiple disease categories

Drug Development - U.S. FDA grants approval to market cefuroxime axetil antibiotic tablets in U.S.

Embryogenesis - Boundary cap cells persist throughout embryogenesis

Embryonic Mutation - Hypomorphic mutation in hnRNP U results in postimplantation lethality

Endometrial Cancer - Increased IL-6 serum levels associated with uterine serous papillary histology

Epstein-Barr Virus - Latent EBV induces remission of splenic lymphoma with villous lymphocyte

Fanconi Anemia - Gene discovery sheds light on causes of rare disease, cancer

Finance - Biopharmaceutical company reports second quarter 2005 financial results

Finance - Lab-products provider reports profitable first quarter

Finance - PolyHeme developer reports $20.3 million loss for the fiscal year

Finance - Polymer-based membranes developer announces net sales of $112.6 million

Gastrectomy - Preoperative imaging of surrounding arteries by 3D-CT aided gastrectomy studied

Gastric Cancer - Overexpression of MUC13 associated with intestinal-type gastric cancer

Glioblastoma Multiforme - Efficacy of temsirolimus in recurrent glioblastoma multiforme evaluated

HIV/AIDS & Tuberculosis Coinfection - Parotid mycobacteriosis often caused by M. tuberculosis in advanced AIDS

HIV/AIDS Diagnostics - HIV-1 RNA from dried-blood spot samples correlates with plasma viral load

HIV/AIDS Drug Development - HIV-1 protease inhibitor derivatives have antiviral activity

HIV/AIDS Drug Development - Nucleoside analog exerts antiviral effects via mutagenesis of HIV genome

HIV/AIDS Epidemiology - Increasing trend of HIV-seropositive migrants in Greece

HIV/AIDS Exposure - CD91 expression increased on monocytes of exposed/HIV-1-seronegative subjects

HIV/AIDS HAART - Racivir safe and effective in HAART-naive HIV-infected patients

HIV/AIDS Pathogenesis - HIV-1 Env-dependent cell-cell fusion modulation related to disease progression

HIV/AIDS Pathogenesis - HIV-1 Tat induces VCAM-1 expression in pulmonary artery endothelial cells

HIV/AIDS Pathogenesis - HIV-1 pol replication capacity predicts disease progression

HIV/AIDS Pathogenesis - New data illuminates research in HIV/AIDS pathogenesis

HIV/AIDS Pathogenesis - Oligoclonal T cells infiltrate the brains of children with AIDS

HIV/AIDS Postexposure Prophylaxis - HIV postexposure prophylaxis not routinely offered following sexual assault

HIV/AIDS Research - Biological assay system demonstrates human retroviral protease activity

HIV/AIDS Research - R5/R5X4/X4 HIV-1 subtype C envelope glycoproteins expressed in insect cells

HIV/AIDS Research - Recent findings illuminate research in HIV/AIDS

HIV/AIDS Risk Behavior - Safe sex practices declined with the introduction of HAART

HIV/AIDS Screening - HIV infection detected in emergency department screening in low prevalence area

HIV/AIDS-Associated Disease - Eye is unlikely to be a site of productive or latent cytomegalovirus persistence

HIV/AIDS-Associated Disease - Poor performance status/HAART absence predicts shorter survival in KSHV/HHV8

HIV/AIDS-Related Dementia - CSF viral load correlates with phase of HIV-associated dementia

Heart Surgery - Aprotinin plus cell salvage effectively lowers transfusion needs

Hematology - CryoStor improves cryopreservation of peripheral blood mononuclear cells

Hematopoiesis - STAT5 activation has role in SC self-renewal in normal/leukemic hematopoiesis

Hemophilia - Gene therapy advance treats blood disorder in mouse models

Hemophilia - Product trial offered for Kogenate FS

Hemophilia Complications - Researchers analyze HCV and HIV in co-infected hemophiliacs

Hepatitis B Virus - Minipool nucleic acid testing effective against transfusion-transmitted HBV

Hepatitis Testing - New blood screening assay effective in detecting HIV, HCV, and HBV

Herbicide Exposure - Short-term herbicide atrazine exposure is immunotoxic

Histamine - Study investigated whether histamine induces TF expression in vascular cells

Homocysteine - Folic acid supplementation does not influence hemostasis markers

Human Herpesvirus Type 8 - Saliva may be a reservoir for human herpesvirus type 8

Hydroxyurea - Hydroxyurea therapy used for sickle cell disease in community-based practices

Hypercholesterolemia - Fibrates have no influence on platelet function within 1 month of therapy

Imaging - California institute debuts 3-D image-guided spinal surgery navigation system

Imaging - MRI allows high-resolution imaging of bone precursor cells in intact BM cavity

Information Technology - Service selected to manage and distribute bone marrow information

Ischemia - Ischemic injury studied, effects on chronic damage in renal grafts revealed

Ischemia - Liver ischemia-reperfusion analyzed, hepcidin modulation revealed

Ischemia - Skeletal muscle studied, effect of ischemia/reperfusion on CXC chemokine defined

Ischemia-Reperfusion - Results underscore importance of studying the naive microcirculation

Kidney Restoration - Tubular cell restoration during kidney repair occurs independent of BM SCs

Leukemia - 5-Aza-2'-deoxycytidine combined with valproic acid to treat leukemia

Leukemia - HRQOL of mothers of children with leukemia in Japan evaluated

Leukemia - Immune system finding paves way for vaccine use in leukemia, lymphoma

Leukemia - Reports advance knowledge in leukemia research

Leukemia - Risk of lung cancer and leukemia from exposure to ionizing radiation studied

Leukemia - Somatic hypermutation linked to leukemia via alteration of BCR autoreactivity

Leukemia - Xanthoangelol induced apoptosis in neuroblastoma and leukemia cells

Leukemia Vaccine - Leukemia-derived dendritic cells generated from myelodysplasia patients

Lou Gehrig Disease - Preinvestigational device exemption application submitted for NuroPro Blood Test

Lung Cancer - Rad51 associated with decreased survival with nonsmall-cell lung cancer

Malaria - Findings in malaria provide new insights

Malaria Vaccine - Quantitative real-time PCR method for malaria diagnosis developed

Medical Devices - Company announces U.S. FDA clearance and U.S. launch of extraction catheter

Mercury Exposure - Umbilical cord mercury level is biomarker of prenatal methylmercury exposure

Multiple Myeloma - STAT1/STAT2 expression in MM does not correlate with response to IFN therapy

Myelodysplastic Syndrome - AML1 gene mutations linked to radiation-associated acute myeloid leukemia

Myelodysplastic Syndrome - Azacitidine is new agent for myelodysplastic syndromes

Neolignans - Neolignans from Saururus chinensis showed cytotoxic effects in cancer cells

Neurogenesis - Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells

Neurogenesis - Suppression of Stat3 promotes neurogenesis in neural stem cells

Neuropathy - Malfunctioning bone marrow cells sabotage nerve cells in diabetes

Neuroprotection - Caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity

Patents - Hidden Patterns wins patent

Pediatric Cancer - Cooperative effort proposed to improve outcomes of childhood cancer

Personnel - Maker of cardiovascular assist devices announces management transition

Pneumococcal Vaccine - Antibodies to pneumococcal protein protect against Streptococcus

Prophylactic Antibiotics - Efficacy of oral prophylactic antibiotics in oncology patients examined

Pulmonary Hypertension - Company completes European Union process for pulmonary hypertension treatment

Quality of Life - Proxy assessment of quality of life in pediatric clinical trials performed

Radiation Exposure - 50 Hz EMF radiation promotes early maturation in newborn granule neurons

SARS Coronavirus - Findings in SARS coronavirus provide new insights

Salmonella Enteritidis Outbreaks - Multiresistant S. enteritidis strains associated with foodborne outbreaks

Simian Immunodeficiency Virus - Simian immunodeficiency virus characterized from a black mangabey

Spermatogenesis - Spermatogonial SCT from leukemic mice restores fertility without leukemia

Spondyloarthropathy - BMP is an attractive target for combating spondyloarthropathies

Staphylococcal Vaccine - Peptide mimics TRAP antigen epitope of Staphylococcus aureus

Stem Cell Research - Adipose-derived stem cells undergo neurogenesis in vitro

Stem Cell Research - BM differentiation into cultured liver cells increases with HGF concentration

Stem Cell Research - Blood origin endothelial cells expanded in closed culture system

Stem Cell Research - Dexamethasone inhibits maturation/alters function of monocyte-derived DCs

Stem Cell Research - Embryonic lung side population cells are hematopoietic and vascular precursors

Stem Cell Research - Hox genes play role in CNS patterning during early development

Stem Cell Transplantation - AML disease burden may identify patients more likely to benefit from second SCT

Stem Cell Transplantation - CD31 genotype may influence function of donor-derived leukocytes for SCT

Stem Cell Transplantation - Race associated with early bacteremia following pediatric SC transplantation

Stem Cell Transplantation - Risk factor associated with antimicrobial therapy failure after HSCT determined

Tissue Engineering - Cryoinjury model uses engineered tissue equivalents for cryosurgery applications

Tissue Engineering - Initial cell seeding density effects temporomandibular joint disc regeneration

Tissue Engineering - Optimal construct determined for generation of muscle-derived stem cells

Tissue Engineering - Perfusion bioreactor investigates cell interactions in tissue engineering

Tissue Engineering - Studies add new findings to tissue engineering body of knowledge

Tissue Regeneration - Bone marrow stromal cells generate muscle cells and repair muscle degeneration

Toxoplasma Gondii - Anti-Toxoplasma gondii IgG antibodies in saliva detected by Western blot

Transplant Medicine - Findings describe new data in transplant medicine research

Transplantation Medicine - Hepatitis B core antibody positive donors safe for lung transplantation

Tuberculosis Drug Development - Oxazolidinones active against M. tuberculosis-infected macrophages

Vascularization - Vessel maturation dependent on integrin alpha-4 beta-1/VCAM-1 mediated adhesion

Wound Healing - MSCs may interact with epidermal keratinocytes to accelerate wound healing

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