Tuberculosis Drug Development

Oxazolidinones active against M. tuberculosis-infected macrophages

Published in Blood Weekly, September 15th, 2005

Oxazolidinones are active against Mycobacterium tuberculosis-infected macrophages.

"The decision to develop a new chemical entity should not only be based on its ability to inhibit multidrug-resistant tuberculosis (MDR-TB) strains but also on its ability to enter macrophages and be active against intracellular bacteria.

"RBx 7644 and RBx 8700, two novel extended spectrum oxazolidinones, were investigated for their activity against sensitive and MDR isolates of Mycobacterium tuberculosis and for activity against bacteria within a macrophage cell line," wrote investigators in India.

"RBx 8700 showed excellent in vitro...

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Source: Blood Weekly (2005-09-15)

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