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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . September 22nd, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Banking - CD34+ cell recovery from cryopreserved autologous stem cell products variable

Blood Safety - Exposure levels of di(2-ethylhexyl) phthalate from blood bags reported

Stem Cell Research - Blood bank notes discovery of embryonic-like stem cells in umbilical cord blood

Tissue Engineering - Bone is formed by hMSCs in biodegradable scaffolds that release Dex/AsP

Tissue Engineering - Tissue engineering techniques used for rotator cuff regeneration

Acute Coronary Syndrome - Clinical trial evaluating rNAPc2 as heparin replacement enrollment initiated

Acute Lymphoblastic Leukemia - ALL subtypes originate, transform at distinct hematopoietic development stages

Anemia - Impact of weekly dosing of epoetin alfa on anemic cancer patients examined

Anemia - Pretreatment anemia associated with poorer survival in gastric cancer patients

Anemia - Researchers discover new pathway for the synthesis of heme in zebrafish

Angiology - Platelets play an indirect role in the regulation of new vessel formation

Hematology - Recent findings in hematology described

Angiology - Risk of catheter-related bloodstream infection assessed

Angiology - Thrombin-stimulated platelets examined, tyrosine phosphorylation revealed

Antiphospholipid Syndrome - Antiphospholipid syndrome studied, FXII antigenic binding sites clarified

Apoptosis - Apoptosis-based therapies for hematologic malignancies discussed

Artificial Organs - Numerical-hydraulic circulatory model developed

Biomedical Engineering - Combined growth factors enhance marrow cell driven bone regeneration

Tissue Engineering - Researchers' work adds to tissue engineering body of knowledge

Bioterrorism - Dutch biotech, U.S. Navy to test AdVac-based vaccine against anthrax, plague

Bone Marrow - Host gammadelta T cells appear to exacerbate GVHD

Business & Finance - Stem cell company reports second quarter 2005 results

Business Update - Medical device firm signs lease on building for stem cell research facility

Cancer Risk Factors - Risk of cancer increased among siblings of long-term childhood cancer survivors

Cancer Therapy - Toxicity predicts effective chemotherapy dose

Cardiolpulmonary Bypass - Transfusion of blood from bypass circuit increased postop hematocrit

Cardiopulmonary Bypass - Nitric oxide treatment may reduce postperfusion lung injury

Chemotherapy - Mylotarg administered after start of chemotherapy produced high remission rate

Chronic Myelogenous Leukemia - Protein kinase inhibitors put under high throughput screening

Cisplatin - Efficacy and safety of intravenous topotecan combinatory chemotherapy tested

Clinical Trials - Amendment to IND for pilot study of blood substitute in brain injury submitted

Collaborations - Alliance deal signed for stem cell banking

Colon Cancer - High oxygen radical production found in patients with sporadic colorectal cancer

Congenital Heart Disease - Activation of platelets by high shear rate is possible within grafts

Coronary Artery Bypass - Kidney transplant patients have bypass survival advantage

Diagnostics - Acute dengue fever diagnosed by both RT-PCR and IgM detection

Diagnostics - Plasma chemokines predict the efficacy of hepatitis C antiviral therapy

Digestive Bleeding - Capsule endoscopy superior to standard diagnostic tests

Dlk1 Overexpression - Dlk1 may be overexpressed in myelodysplastic syndrome and acute myeloid leukemia

Drug Development - Nebulization of SLP-based antitubercular drugs improves bioavailability

Drug Development - Study of isatoribine in hepatitis C demonstrates proof of concept

Embryonic Cell Transplantation - Serum deprivation decreases rate of embryonic cell death after transplantation

Epstein-Barr Virus - Researchers' findings advance epstein-barr virus research

Feline Immunodeficiency Virus - IgG from acutely infected cats blocks mucosal FIV infection

Finance - Carbohydrate drug-development company comments on Q2 loss

Finance - Drug delivery company completes private financing

Genetics & Genomics - Preabsorption with protein-L: A tool for removing interfering immunoglobulins

HIV/AIDS HAART - Lopinavir CSF concentrations exceed the 50% inhibitory concentration for HIV

HIV/AIDS Hemophilia - HLA antigens predict disease progression in HIV-infected hemophilia patients

HIV/AIDS Pharmacogenetics - Mutations related to altered drug pharmacokinetics influences HAART efficacy

HIV/AIDS Vaccines - Researchers' work adds to HIV/AIDS vaccines body of knowledge

HIV/AIDS Viremia - HIV RNA blips during HAART may reflect ongoing viremia which impair CD4 recovery

Hematology - New findings in hematology described

Hematopoiesis - Angiopoietins accelerate marrow vessel regeneration after myelosuppression

Hemodialysis - Hemodynamics in punctured vascular access grafts characterized

Hemodialysis - Implementation of DOQI vascular access guidelines lowers morbidity

Hepatitis C Virus - Serum copper and zinc levels are unchanged in patients with chronic hepatitis C

Immunopharmacology - UTE appears to indirectly modulate immune activity

Kaposi Sarcoma-Associated Herpesvirus - Researchers provide details of new studies and findings in the area of kaposi sarcoma-associated herpesvirus

Kidney Cancer - Multidetector computed tomography compared to magnetic resonance imaging

Leukemia - Ethnic difference in daycare attendance and early infections related to ALL risk

Leukemia - Health watch exposure estimates underestimated benzene exposure

Leukemia - Protocol for the treatment of newly diagnosed APL children delineated

Leukemia - Wnt16 inhibition induced apoptosis in ALL cells

Liver Cirrhosis - HIV coinfection cuts survival in those with HCV-related decompensated cirrhosis

Lymphoma - Relation between benzene exposure and non-Hodgkin lymphoma studied

Lymphoma - STAT5 is a modifier of interleukin-7-induced lymphomas

Mental Health - Patients with hematological malignancies showed a restricted body image

Multiple Myeloma - Researchers find celecoxib is tough tumor fighter

Mycobacteria Abscessu Outbreaks -  Mycobacteria abscessu outbreak in U.S. linked to offshore surgicenter

Myelodysplastic Syndrome - Aberrant SOCS-1 methylation induces transcriptional silencing in myeloid cells

Myeloma - Zoledronic acid down-regulated adhesion molecules of bone marrow stromal cells

Myocardial Infarction - Self mesenchymal stem cells and endothelial progenitors aid infarcted hearts

Neurogenesis - Shc3 affects high-grade astrocytoma survival

Norwalk Virus - Secretor status most predictive of risk of Norwalk virus infection

Oncology - Recombinant human erythropoietin suppresses intratumoral blood vessels

Ovarian Cancer - Topotecan in pretreated patients with recurrent ovarian carcinoma evaluated

Personnel - Blood bank company appoints Mercedes Walton CEO

Personnel - Dr. Linda Rhodes of AlcheraBio joins board

Personnel - Six new members join blood cancer research funding group's board of directors

Platelets - Findings in platelets provide new insights

Platelets - Mucetin-activated platelets analyzed, translocation to cytoskeleton clarified

Platelets - Platelet activation analyzed, role of lipid rafts defined

Platelets - Platelet activation analyzed, roles of Tyr phosphorylation defined

Product Licensing - Pharma company acquires rights for novel oral phosphate binder

SARS - New research in the area of SARS detailed

Sepsis - Diagnostics company and Biosite collaborate to develop diagnostics for sepsis

Sickle Cell Disease - New ways to prevent stroke and reduce excess iron in sickle cell anemia studied

Solid Tumors - Epoetin alfa 40000 U once weekly and intravenous iron supply treated solid tumor

Space Medicine - Simulated hypogravity alters the angiogenic response of endothelial cells

Stem Cell Research - Bmi-1 promotes neurogenesis by repressing P16Ink4a/P19Arf senescence pathways

Stem Cell Research - CD144 is transiently expressed by fetal liver hematopoietic stem cells

Stem Cell Research - Complications endure after stem cell transplants in patients with hepatitis B

Stem Cell Research - Embryonic stem cell lines generated from poor quality day 3 embryos

Stem Cell Research - Ink4a and Arf differentially affect cell proliferation and NSC self-renewal

Stem Cell Research - Interleukin-4 effects on intestinal mast cell functions are reversible

Stem Cell Research - Intestinal mast cell growth/phenotype/function tightly regulated by TGF-beta1

Stem Cell Research - Monoclonal side population progenitors isolated from fetal pancreas

Stem Cell Research - Osteopontin negatively regulates stem cell pool size

Stem Cell Research - P21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression

Stem Cell Research - Skeletal muscle has been generated from transplanted embryonic stem cells

Stem Cell Transplantation - Donor CD31 codon 125 genotype correlates with acute GVHD incidence in HSCT

Stem Cell Transplantation - Donor cell allodepletion may reduce severe acute GVHD rate in older patients

Stem Cell Transplantation - KIR genotype protects against leukemic relapse after related HLA-identical HSCT

Stem Cell Transplantation - Leaving central vein catheters in place does not increase SCT-related morbidity

Stem Cell Transplantation - Noninvasive oral rinse monitors neutrophil tissue delivery timing in SCT

Thrombosis - Catheter tip position implicated as risk factor for thrombosis

Tissue Engineering - Data advance knowledge in tissue engineering research

Tissue Engineering - Tissue engineered ceramic artificial joint used to treat osteoarthritis

Tissue Engineering - Wound re-epithialization observed following skin substitute transplantation

Transplant Medicine - Edaravone reduces cold I/R injury in canine renal autografts

Transplant Medicine - Some children face bone marrow transplant risk from dental problems

Tuberculosis Risk Factors - HLA haplotypes related to tuberculosis risk or resistance

Vinorelbine - Vinorelbine combined with gemcitabine in previously treated SCLC patients

West Nile Virus - Recent findings illuminate research in west nile virus

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