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Chronic Myelogenous Leukemia

Protein kinase inhibitors put under high throughput screening

Published in Blood Weekly, September 22nd, 2005

Protein kinase inhibitors have been put under high throughput screening.

According to recent research published in the journal Combinatorial Chemistry & High Throughput Screening, "The pivotal role of kinases in signal transduction and cellular regulation has lent them considerable appeal as pharmacological targets across a broad spectrum of pathologies. Since the discovery that the v-Src oncogene encoded a protein kinase in 1978, kinases have remained a focus of research for pharmaceutical laboratories and academic groups alike."

"Many have sought to develop orally available low molecular weight synthetic kinase modulators (predominantly...

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