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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . September 29th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Banking - Accuracy and efficacy determined for three platelet pheresis machines

Sickle Cell Anemia - Research hospital to lead trial to investigate sickle cell anemia and stroke

Stem Cell Cryopreservation - Model facilitates the cryopreservation of intact adherent hES cell colonies

Tissue Engineering - MSC and hydroxyapatite ceramic transplant treats severe osteochondral damage

Tissue Engineering - Tissue-engineered bone can be used for early stage bone regeneration

Adverse Drug Reaction - Agency discusses glucosamine and elevated cholesterol

Alcohol Use - Alcohol impairs astrogliogenesis by stem cells in neurospheres

Allograft Rejection - Compound targeting CCR5/CXCR3 prevents acute and chronic allograft rejection

Assisted Reproduction - Mouse ESC used for quality control testing in assisted reproductive technology

Atherosclerosis - Atherosclerosis studied, loss of receptor-mediated lipid uptake clarified

HIV/AIDS Pathogenesis - Researchers publish new studies and findings in the area of HIV/AIDS pathogenesis

Blood Clotting - Coagulation cascade analyzed, regulation of mediated initiation defined

Blood Clotting - Factor XIa examined, role of dimer in factor IX activation defined

Bone Marrow - Three genes studied as new G-CSF targets during neutrophilic differentiation

Bone Marrow Transplants - Campath-1H does not appear to alter bone marrow cell regulatory function

Breast Cancer Therapy - Femara granted FDA priority review for new indication: early breast cancer

Business Update - Blood volume analyzer purchased by the Queens Medical Center in Honolulu, Hawaii

Leukemia - Findings advance knowledge in leukemia research

Business Update - Manufacturer of drug delivery systems sells GFI Clinical Services unit

Cancer Research - Efficient synthesis of fluorothiosparfosic acid analogues achieved

Cancer Risk Factors - Studies describe new findings in cancer risk factors research

Cancer Therapy - Adjuvant chemotherapies evaluated in locally advanced bladder cancer

Cancer Therapy - Doxorubicin/fluorouracil compared with streptozocin/fluorouracil or dacarbazine

Catheter Ablation - Trans-catheter ablation approach affects delayed cure rate

Leukemia - Researchers describe findings in leukemia studies

Central Nervous System Development - Rybp/DEDAF required for early postimplantation and CNS development

Chronic Hepatitis C Virus - Hepatitis C infection remains stable despite therapy-induced neutropenia

Collaborations - Alliance formed to develop, manufacture and commercialize nucleic acid testing

Collaborations - Biotech company and The Scripps Research Institute extend collaboration

Coronary Artery Bypass - Long-term serial angiographic outcome characterized

Cytomegalovirus - CMV in transplanted allografts stimulates self HLA release from responding PBMCs

Leukemia - Studies advance knowledge in leukemia research

DNA Research - Functions of tumor suppressor p53 clarified

Diagnostics - Findings describe new data in diagnostics research

Diagnostics - Study finds potentially better test for infant iron deficiency

Disease Associations - Primary hyperlipidemia examined, association of clinical indicators clarified

Drug Development - Xechem UK formed to file orphan drug application in E.U. for sickle cell drug

Drug Resistance - Cephalosporin-resistant pneumococci common in patients

Stem Cell Research - Reports add new data to stem cell research

Environmental Health - 34+ HSCs are targets for carcinogenic polycyclic aromatic hydrocarbons

Epidemiology - Atopy linked to lower cancer risk

Erythropoiesis - Adducin gene expression regulated in gene-specific manner during erythropoiesis

Finance - Grant announced to create proprietary BioFactories for sepsis

Gastric Cancer - Docetaxel plus cisplatin used as second-line combined therapy in gastric cancer

Gastric Cancer - Pretreatment anemia associated with poorer survival in gastric cancer patients

Transplant Medicine - Recent findings in transplant medicine described

Genetics & Genomics - Human cathelicidin antimicrobial peptide gene targeted by vitamin D receptor

Graft-versus-Host Disease - Anti-4-1BB monoclonal antibody prevents and treats chronic GVHD

Graft-versus-Host Disease - IL-6 and IL-10 promoter gene polymorphisms associated with increased GVHD risk

HIV/AIDS Pathogenesis - Research in HIV/AIDS pathogenesis provides new insights

Hematology - Fewer hemodialysis patients in Brazil are acquiring hepatitis C infection

Transplant Medicine - Researchers' data advance transplant medicine research

Hematology - New findings in the area of hematology described

Hematopoiesis - Mice severely deficient in growth hormone have normal hematopoiesis

Hemodialysis - Citrate anticoagulation feasible during single-needle hemodialysis

Hepatitis B Virus - Hepatitis B vaccine response fails in liver graft patients receiving lamivudine

High-Grade Gliomas - High-dose methotrexate administered prior to simultaneous radiochemotherapy

Homeostasis - Hemojuvelin examined, role in dietary iron sensing defined

Hypopituitarism - Effect of replacement therapy with hydrocortisone or levothyroxine studied

Infections - Dengue virus replication analyzed, nitric oxide suppression revealed

Infections - Stromal cells analyzed, role in B-cell-B-cell contact and maturation defined

Ischemia - JAM-A has role in polymorphonuclear diapedesis through vessel wall

Ischemia - PGE1 induces heat-shock proteins after ischemia of mouse liver

Kaposi Sarcoma-Associated Herpesvirus - Researchers report details of new studies and findings in the area of kaposi sarcoma-associated herpesvirus

Kidney Transplantation - Long-term outcome of renal artery stenosis characterized

Leukemia - Data advance knowledge in leukemia research

Leukemia - Novel induction therapy for refractory acute myeloid leukemia reported

Liver Transplantation - Outcome of right-lobe living donation clarified

Lung Cancer - Carboplatin and weekly paclitaxel used in NSCLC patients unfit for chemotherapy

Lung Cancer - Irinotecan and amrubicin treated patients with non-small-cell lung cancer

Medical Devices - Novel multiobjective algorithm improves hemodynamic control

Medical Devices - Transfemoral approach expands venous access routes

Myeloma - HDAC inhibitors and TRAIL associated with changes in mitochondrial functions

Myeloma - Multiple Myeloma Resource Line launched

Myocardial Infarction - Sirolimus-eluting stents effective in primary angioplasty

Myocardial Infarction - VF patients show enhanced coagulation after in vitro LPS challenge

Nephrology - Utility of convective dialysis therapies reviewed

Neurogenesis - Gab2 is an important player in neural differentiation

Oral Cancer - Association among factor V, prothrombin mutations, and oral cancer risk studied

Ovarian Cancer - Interleukin-6 evaluated as marker of prognosis for women with ovarian cancer

Pancreatic Cancer - Late complication occurred after pancreatic resection with radiation therapy

Polymerase Chain Reaction - PCR assay for dual detection of bacteria and parasites developed

Product Licensing - Expansion of Amgen collaboration, license agreement from Johns Hopkins announced

Product Licensing - Rights to develop certain antistaphylococcal monoclonal antibodies licensed

SARS - Recent findings in SARS described

Sepsis - Company updates clinical trials for eritoran as a treatment for severe sepsis

Sepsis - Endotoxemia studied, inhibitory hydroxyethyl starch effects defined

Stem Cell Research - Adipose-derived stromal cells differentiate into neural lineages

Stem Cell Research - Death receptors, Fas, and TRAIL receptors are involved in osteoclast apoptosis

Stem Cell Research - Embryonic endothelial progenitor cells ameliorate acute and chronic ischemia

Stem Cell Research - Embryonic stem cell line expressing EGFP useful for regeneration research

Stem Cell Research - Oocytes generated in adult ovaries by putative germ cells in bone marrow

Stem Cell Research - Preclinical study indicates umbilical cord stem cells improve heart function

Stem Cell Research - Recent studies add new data to stem cell research

Stem Cell Research - Satellite cells are self-sufficient as a source of regeneration

Stem Cell Research - Sca-1 overexpression decreases myeloid activity of progenitors cells

Stem Cell Research - Sox15 and Sox2 have differential roles in transcriptional control in ES cells

Stem Cell Research - Stromal-based serum-free culture system supports stem cell growth & maintenance

Stem Cell Transplantation - Persistent nucleated red blood cells a poor prognostic factor for STC patients

Stem Cell Transplantation - Stem cell-derived brain implants suppress seizures by paracrine mode of action

Surgical Technology - Amplatzer septal occluder successfully used in percutaneous closure

Surgical Technology - Circumferential pulmonary vein ablation systems compared

Surgical Technology - Distally based sural flap useful in treatment of chronic venous ulcers

Surgical Technology - OrthoPAT surgical blood salvage system to be marketed by U.S. direct sales force

Thalidomide - Thalidomide and celecoxib evaluated in patients with multiple myeloma

Thrombosis - Central venous catheter-related thrombosis prevented with minidose warfarin

Thrombotic Thrombocytopenic Purpura - Short heparin-free hemodialysis lowers citrate load during plasma exchange

Tissue Engineering - Conjugated hydrogel promotes MSC osteogenesis in a dosage-dependent manner

Transplant Medicine - Advanced donor age worsens outcomes after liver transplantation for hepatitis C

Transplant Medicine - Human hepatitis C immune globulin appears safe in liver transplant recipients

Transplant Medicine - New research in the area of transplant medicine detailed

Tumorigenesis - Nucleosternin may play an important role in tumorigenesis

Venous Thromboembolism - Clinical impact of anticoagulation duration determined

Virology - Hepatitis A virus load governs disease severity and clinical manifestation

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