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Bone Marrow

Three genes studied as new G-CSF targets during neutrophilic differentiation

Published in Blood Weekly, September 29th, 2005

The identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic differentiation was studied.

According to recent research published in the Journal of Leukocyte Biology, "Granulocyte colony-stimulating factor (G-CSF) is a cytokine that stimulates myeloid progenitor cells to proliferate and differentiate into neutrophilic granulocytes. To identify genes induced by G-CSF during neutrophil differentiation, interleukin-3-dependent murine myeloid precursor FDC-P1 cells expressing the G-CSF receptor were stimulated with G-CSF, and the gene expression profile was characterized by DNA microarray analysis."

"In addition...

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