Leukemia
2-Methoxyestradiol at low dose induced differentiation of myeloma cells
Published in Blood Weekly, October 6th, 2005
"Previous studies showed that 2ME2 could suppress the proliferation of myeloma cells and induce their apoptosis. In the present study, we found that treatments with low-concentration of 2ME2 resulted in some maturing morphological changes of myeloma cells," researchers from the People's Republic of China reported.
"Flow cytometric analysis showed that the expression of CD49e on the myeloma cells surface was significantly increased by 2ME2. Moreover, 2ME2 increased the secretion of light chain protein remarkably. Furthermore, the expressions of transcription factor XBP-1...
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Source: Blood Weekly (2005-10-06)
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