Stem Cell Research
Cellular FLICE-inhibitory protein required for T cell survival and cycling
Published in Blood Weekly, October 13th, 2005
According to recent research published in the Journal of Experimental Medicine, "Fas-associated death domain (FADD) and caspase-8 are key signal transducers for death receptor-induced apoptosis, whereas cellular FLICE-inhibitory protein (cFLIP) antagonizes this process.
"Interestingly, FADD and caspase-8 also play a role in T cell development and T cell receptor (TCR)-mediated proliferative responses."
"To investigate the underlying mechanism," investigators said, "we generated cFLIP-deficient T cells by reconstituting Rag-/- blastocysts with...
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Source: Blood Weekly (2005-10-13)
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