Leukemia

Effects of sample source and test methodology on prognosis of AML examined

Published in Blood Weekly, October 20th, 2005

Researchers examined the effects of sample source and test methodology on the prognosis of acute myelogenous leukemia (AML).

"Numerous studies have analyzed the expression and prognostic importance of various proteins in AML. We sought to determine whether the sample source and methodology used to measure protein expression affect the results obtained," scientists writing in the journal Leukemia reported.

"To determine the importance of sample source, we used Western blotting to compare the expression of 8 proteins and phosphoproteins in the leukemia blast-enriched fraction of 118 blood- and 108 marrow-derived samples, including 37 paired...

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Source: Blood Weekly (2005-10-20)

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