Malaria
New findings in the area of malaria described
Published in Blood Weekly, October 27th, 2005
Study 1: Potent inhibitors of malarial plasmepsin I and II have been synthesized.
"New and potent inhibitors of the malarial aspartic proteases plasmepsin (Plm) I and II, from the deadliest malaria parasite Plasmodium falciparum, have been synthesized utilizing Suzuki coupling reactions on previously synthesized bromobenzyloxy-substituted statine-like inhibitors.
"The enzyme inhibition activity has been improved up to eight times by identifying P1 substituents that effectively bind to the continuous S1-S3 crevice of Plasmepsin I and II,"...
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Source: Blood Weekly (2005-10-27)
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