Proteomics

More proteins accumulate in stored supernatants of nonleukoreduced than in leukofiltered RBC products

Published in Blood Weekly, November 3rd, 2005

More proteins accumulate in stored supernatants of nonleukoreduced red blood cell products compared with leukofiltered RBC products.

According to recent research published in the journal Transfusion, "The development of the red blood cell (RBC) storage lesion remains incompletely understood.

"To gain a greater insight into the mechanisms involved, a proteomics analysis was used to identify proteins that accumulate in supernatants of standard nonleukoreduced RBC products (S-RBCs) and prestorage leukofiltered RBC products (LF-RBCs) during storage."

"S-RBCs and LF-RBCs were collected and stored in accordance with standard...

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Source: Blood Weekly (2005-11-03)

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