Stem Cell Research

Interleukin-4 is essential for the expression of Ym1/2 genes

Published in Blood Weekly, November 10th, 2005

Interleukin-4 is essential for the expression of Ym1/2 genes.

"Mast cells play an important role in allergic inflammation by releasing various bioactive mediators. The function of mast cells is enhanced by various stimuli, partly due to the induction of specific genes and their products. Although many inducible genes have been identified, a significant number of genes remain to be identified.

"Therefore, this study used PCR-selected cDNA subtraction to establish the profile of induced genes in the connective tissue (CT) type-like mast cells derived from bone marrow cells cultured in the presence of IL-4 and stem cell factor," wrote scientists in...

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Source: Blood Weekly (2005-11-10)

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