Leukemia

Researchers' work adds to leukemia body of knowledge

Published in Blood Weekly, November 17th, 2005

Leukemia data are the focus of recent research from Italy and the United States.

Study 1: Nucleophosmin (NPM) mutations were found in childhood acute myelogenous leukemia (AML) with normal karyotype.

"NPM is a nucleocytoplasmic shuttling protein involved in leukemia-associated chromosomal translocations, and it regulates the alternate reading frame (ARF)-p53 tumor-suppressor pathway. Recently, it has been demonstrated that mutations of the NPM1 gene alter the protein at its C-terminal, causing its cytoplasmic localization," researchers in Italy reported.

"Cytoplasmic NPM was detected in 35% of adult patients with primary...

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Source: Blood Weekly (2005-11-17)

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