Published in Blood Weekly, November 17th, 2005
"NPM is a nucleocytoplasmic shuttling protein involved in leukemia-associated chromosomal translocations, and it regulates the alternate reading frame (ARF)-p53 tumor-suppressor pathway. Recently, it has been demonstrated that mutations of the NPM1 gene alter the protein at its C-terminal, causing its cytoplasmic localization," researchers in Italy reported.
"Cytoplasmic NPM was detected in 35% of adult patients with primary...
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