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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . November 24th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Safety - Study shows ligand technology effective in removing blood-borne TSE infectivity

Diagnostics - Blood bank safety advanced with U.S. launch of hepatitis test

Stem Cell Transplantation - Increased TNF levels associated with increased risk of CMV infection after AHSCT

Stem Cell Transplantation - Protein C levels during HSCT conditioning do not predict veno-occlusive disease

Adverse Drug Reaction - Patients develop acute liver failure after receiving amoxicillin/clavulanate

Allergy & Immunology - Donor HLA alleles may control hepatitis C virus spread to liver grafts

Alzheimer Disease - High-resolution serum proteomic profiling developed for Alzheimer disease detection

Angioplasty - Ischemic preconditioning may attenuate regional release of inflammatory markers

Atherosclerosis - Neovessel instability may cause intraplaque hemorrhage in atherosclerotic lesions

Biomedical Engineering - Degradable PEG porous tubes can be used as nerve guidance channels

Hematology - Researchers' findings advance hematology research

Biomedicine - 2,2'-diselenadibenzoic acid may bind to sub-domain IIA sites in serum albumin

Business & Finance - Cholesterol monitor developer ranked on 2005 Deloitte Technology Fast 500 list

Cancer Fatigue - Fatigue in cancer patients not related to changes in oxyhemoglobin dissociation

Cancer Risk Factors - Maternal history of miscarriage associated with increased risk of childhood AML

Cancer Therapy - Anticancer drug gets fast track for elderly with acute myelogenous leukemia

Cancer Therapy - Anticoagulant treatment improved survival in cancer patients

Leukemia - Studies add new findings to leukemia body of knowledge

Cancer Therapy - Cost of epoetin alfa and darbepoetin alfa treatment in Sweden evaluated

Cancer Therapy - Modification of treatment protocols improved outcome of childhood leukemia

Cardiology - Antibodies to heparin pose a risk of adverse events following cardiac surgery

Cardiology - Flow mediated dilation is associated with changes in coronary diameter and coronary blood flow

Cardiovascular Research - Bone marrow-derived myofibroblasts are present in adult human heart valves

Cardiovascular Research - Secondary arteriovenous fistulas underused but highly effective after access failure

Leukemia - Studies describe new findings in leukemia research

Cardiovascular Research - Zinc deficiency influences arterial BP vascular NO pathway in growing rats

Chemotherapy - Chemotherapy induced toxic myelopathy

Chemotherapy - Dose-dense chemotherapy may be superior to CHOP for primary mediastinal large B-cell lymphoma

Chemotherapy - Early efficacy of epoetin alfa superior to darbepoetin alfa

Clinical Trials - Authorization granted for U.K. trial of hemoglobin glutamer in cardiac surgery

Collaborations - NAT maker to collaborate with Molecular Profiling Institute to bolster oncology strategy

Transplant Medicine - Researchers report details of new studies and findings in the area of transplant medicine

Colon Cancer - Aberrant cytochrome c oxidase subunit I expression is biomarker for increased colon cancer risk

Coronary Artery Bypass - Hemodilution and surgical hemostasis strongly influence transfusion need

Cytotoxicity - Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of acute myeloid leukemia

Diabetes Therapy - Patients with nonalcoholic steatohepatitis and type 2 diabetes benefit from nateglinide

Diagnostics - Biochemical marker health assessment tool now widely available

Diagnostics - Capillary electrophoretic method detects glycolysis metabolites in human red blood cells

Diagnostics - D-dimer diagnostic test more accurate than computerized strain gauge plethysmography

Diagnostics - Findings in diagnostics provide new insights

Diagnostics - Novel system enables in vivo analysis of bileaflet prosthesis leakage jet turbulence

Drug Safety - High doses of ibuprofen can cause significant GI bleeding despite its safety profile

Embolism - Cerebral embolism occurred after transcatheter arterial chemoembolization

Endocrinology - Neuroblasts migrate in response to endothelin-1 through involvement of endothelin type B receptors

Finance - Antibody-based drug developer reports net loss; initiates clinical trial

Finance - Biomedical testing company closes $15 million placement with private investors

Finance - Grants support hemophilia advocacy efforts

Fitness & Wellness - Exercise capacity in patients with beta-thalassemia intermedia is not significantly affected

Genetics - A functional polymorphism reduces cardiovascular disease risk in men

Genetics & Genomics - Chromosomal changes used to identify non-MALT marginal zone B-cell lymphomas

Genetics & Genomics - Cooperating cancer genes identified by oncogenic-retrovirus-induced mutagenesis

Genetics & Genomics - Pentameric symmetry loss in CRP induces IL-8 secretion through peroxynitrite signaling

Genetics & Genomics - Platelet glycoprotein IIIa genotype determines effect of aspirin on postoperative bleeding

Graft-versus-Host Disease - Interleukin-4-producing CD8+ cells may be an immunological hallmark of chronic GVHD

Granulocytic Sarcoma - Granulocytic sarcoma manifested as multiple skeletal lesions

Hematology - Hemophiliacs respond satisfactorily to chronic hepatitis C therapy

Hematology - Hepatitis C virus infection may be associated with thrombocytopenia

Hematology - Reports describe recent advances in hematology research

Hemodialysis - Access site reuse preferable to de novo placement for conversion to permanent catheters

Hemophilia - Hemophilia organization announces two fellowships in bleeding disorders research

Hepatitis C Therapy - Tentative approval granted for hepatitis C combination therapy

Hepatitis C Virus - Core-specific precursor T cell response reflects viral load in chronic hepatitis C

Hepatitis C Virus - Serum apoptosis markers increase during treatment for chronic hepatitis C

Imaging - Sonography can detect trisomies and other chromosome abnormalities

Influenza - Children with neurological and neuromuscular diseases should receive annual flu shot

Information Technology - Software for blood donor centers offers selective reporting of parameters

Ischemia - Livers retrieved with short warm ischemia times may be acceptable for transplantation

Leukemia - Combination regimen shown effective in treating B-cell lymphocytic leukemia

Leukemia - Common genetic variants linked to infection risk in children undergoing therapy

Leukemia - Data advance knowledge in leukemia research

Leukemia - Pathogenesis and therapy of acute myelogenous leukemia discussed

Medical Devices - Fenestrated endograft gets CE Mark approval for complex aortic aneurysms

Medical Devices - Georgetown University Hospital acquires BVA-100 blood volume analyzer

Medical Devices - Prototype of non-invasive method to measure hematocrit is complete

Medical Devices - Vasotrac enables noninvasive BP monitoring during prone anesthesia in adolescents

Myelodysplastic Syndromes - Pharma company seeking authorization to market Revlimid in European Union

Neovascularization - Granulocyte-colony stimulating factor augments bone marrow-induced neovascularization

Nosocomial Infections - Vfend equals two-drug candidemia regimen, with fewer serious side effects

Oncology - New data illuminates research in oncology

Pain Management - Flavonoid treatment has little impact on pain or bleeding after ambulatory stapled hemorrhoidopexy

Pediatric Cancer - Malfunctioning events and catheter-related infections occurred rarely

Peptides - An immunoluminometric assay can measure midregional proadrenomedullin in plasma

Peripheral Vascular Disease - Autologous cell implantation improves limb ischemia in patients with peripheral arterial disease

Pharmaceutical Research - Antibiotic daunomycin binds to human serum albumin at nonclassical drug binding site

Pharmacology - LC-MS simultaneously detected loratadine and pseudoephedrine in human plasma

Pharmacology - Microdialysis plus capillary electrophoresis detects trimebutine maleate in rabbit blood

Prognostics - Circulating plasma cells predicted survival in patients with newly diagnosed multiple myeloma

Prognostics - Concentration of thymidine kinase 1 used as proliferation marker in solid tumors

Prognostics - ETV6/RUNX1 rearrangement indicated good prognosis

Prognostics - Imatinib-induced inhibition of ABL kinase activity predicted patient response

Respiratory Medicine - Anticoagulant therapy reduces mortality risk

Spinal Cord Injury - Antibody to IL-6R suppresses secondary injury and glial scar formation in spinal cord injury

Stem Cell Disorders - Telomerase activity in MDS may be insufficient to compensate for telomere shortening

Stem Cell Research - Angiopoietin-2 stimulates endothelial progenitor cell migration

Stem Cell Research - Ascorbic acid promotes osteoclastogenesis from embryonic stem cells

Stem Cell Research - Chronic intrathecal injections of a large volume of fluid increase mast cells in the CNS

Stem Cell Research - ESCs generate progeny by microinsemination of male germ cells from chimeric mice

Stem Cell Research - Electromagnetic fields affect transcript levels of apoptosis-related genes

Stem Cell Research - Embryonic stem cells cocultured with Thy1-positive cells differentiate into hepatocytes

Stem Cell Research - Inflammatory endothelial cells disrupt the repair capacity of endothelial progenitor cells

Stem Cell Research - Neural stem cell differentiation is dependent upon endogenous caspase-3 activity

Stem Cell Research - Neuroprotection by stem cell factor in cortical neurons involves Akt and NF kappa B

Stem Cell Research - Repression of DNA replication licensing in quiescence is independent of geminin

Stem Cell Research - Stem cells may potentially be used to modify aging

Stem Cell Therapy - Infused mesenchymal stem cells enhance recovery from I/R-induced acute renal failure

Stem Cell Transplantation - ACE gene D-allele associated with noninfectious pulmonary dysfunction development after HSCT

Stem Cell Transplantation - Allogenic chimeric mouse model indicate some donor stem cells exist more than 6 months

Stem Cell Transplantation - Bone marrow remains a significant source of stem cells for autologous HSCT

Stem Cell Transplantation - Glutamine reduces the severity of mucositis in children undergoing HSCT

Stem Cell Transplantation - Higher NK cell dose reduces nonrelapse mortality and infectious events after SCT

Stem Cell Transplantation - IIVP salvage regimen yields high response rates before autologous stem cell transplantation

Stem Cell Transplantation - Increased DMSO concentration associated with toxicity in stem cell transplantation

Stem Cell Transplantation - Nonmyeloblative SCT costs the same as myeloblative SCT after considering price of complications

Stem Cell Transplantation - Oral mucosal pathology is common in pediatric patients with cGVHD after HSCT

Stem Cell Transplantation - Perception of problematic social support associated with poor survival after SCT

Stem Cell Transplantation - Prospective monitoring of TNF-alpha and IFN gamma predicts onset of GVHD after ASCT

Stem Cell Transplantation - Risk/benefit ratios of GVHD/graft-versus-leukemia effect differ among diseases

Surgical Technology - SmartSuction HARMONY surgical suction pump cleared by U.S. FDA

Thrombosis - Hemostatic risk factors in predicting arterial thrombotic events clarified

Tissue Engineering - Bioresorbable composites enable adequate suitable properties for bone tissue engineering

Tissue Engineering - Full-thickness cartilage defects of the femoral condyle repaired with implant

Tissue Engineering - Highly differentiated 3D tissues reconstructed by stacking layers of small hepatocytes

Tissue Engineering - Serum deprivation improves repopulation of acellular matrices with valvular interstitial cells

Transplant Medicine - Patients fare well without steroids after hepatitis C-related liver transplants

Transplant Medicine - Researchers provide details of new studies and findings in the area of transplant medicine

Vascular Disease - Data indicate that adipose stem cells form blood vessels and improve blood flow

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