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Increase in microcirculatory blood flow enhances ciprofloxacin diffusion into soft tissue

Published in Blood Weekly, December 1st, 2005

Study reveals that an increase in microcirculatory blood flow enhances penetration of ciprofloxacin into soft tissue.

According to recent research from Austria, "The present study addressed the effect of microcirculatory blood flow on the ability of ciprofloxacin to penetrate soft tissues. Twelve healthy male volunteers were enrolled in an analyst-blinded, clinical pharmacokinetic study."

C. Joukhadar and colleagues at the Medical University of Vienna explained, "A single intravenous dose of 200 mg of ciprofloxacin was administered over a period of approximately 20 min. The concentrations of ciprofloxacin were measured in plasma and in the warmed and...

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