Stem Cell Research

Embryonic stem cell nuclei have a distinct nuclear architecture

Published in Blood Weekly, December 8th, 2005

Embryonic stem cell nuclei have a distinct nuclear architecture, especially at loci involved in maintaining pluripotency.

According to recent research from Scotland, "Nuclear organization is thought to be important in regulating gene expression. [In our report] we investigate whether human embryonic stem cells (hES) have a particular nuclear organization, which could be important for maintaining their pluripotent state."

"We found that whereas the nuclei of hES cells have a general gene-density-related radial organization of chromosomes, as is seen in differentiated cells, there are also distinctive localizations for chromosome regions and gene loci...

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Source: Blood Weekly (2005-12-08)

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