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Tissue Engineering

Apatite-promoted osteoblastic differentiation observed in 3D model system

Published in Blood Weekly, December 8th, 2005

Apatite-promoted osteoblastic differentiation was observed in a 3-dimensional model system.

According to a study from the United States, "Biomimetic apatites have been reported to promote osteogenic activities in numerous in vivo and in vitro models, but the precise mechanism by which the apatite micro-environment promotes such activities is not well understood. Such mechanistic studies require reproducible model systems that are relevant to tissue engineering practices."

"Although 2-dimensional (2D) apatite-coated polystyrene culture dishes provide practicality and reproducibility, they do not simulate the effects of the 3-dimensional (D)...

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