Hematology

Naturally occurring pentacyclic triterpenes reduce blood glucose levels

Published in Blood Weekly, December 15th, 2005

Naturally occurring pentacyclic triterpenes reduce blood glucose levels, most likely by inhibiting hepatic glycogen degradation.

According to recent research published in the journal Bioorganic & Medicinal Chemistry Letters, "The semisynthesis, in vitro and in vivo biological evaluation of corosolic acid (1) and maslinic acid (2) are described."

X.A. Wen and colleagues at the China Pharmaceutical University in Nanging offered, "Compounds 1 and 2 represent a new class of inhibitors of glycogen phosphorylases. Both 1 and 2 inhibit the increase of fasted plasma glucose of diabetic mice induced by adrenaline."

"It is therefore...

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Source: Blood Weekly (2005-12-15)

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